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首页> 外文期刊>Critical care nurse >Low-dose corticosteroids to treat septic shock: a critical literature review.
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Low-dose corticosteroids to treat septic shock: a critical literature review.

机译：低剂量皮质类固醇治疗败血性休克：关键文献综述。

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摘要

Septic shock is the 13th leading cause of death in the United States. The rate of severe sepsis nearly doubled and mortality increased more than 60% during the 10-year period ending in 2003. Systemic inflammatory response syndrome has noninfectious and infectious causes. Noninfectious ones include burns, trauma, severe pancreatitis, and therapy with monoclonal antibodies or immunomodulatory drugs such as interleukin 2. Progression from sepsis syndrome to septic shock is caused by a series of immune responses. As an infectious injury progresses, host activation of the coagulation, immunological, and stress response systems ensues, resulting in tissue hypoperfusion and organ failure. Early studies with small numbers of patients suggest that treatment with low-dose corticosteroids has marked beneficial effects on shock reversal, the immune system, and the hemodynamic profile. Low-dose corticosteroids should only be administered to a subset of patients with septic shock who are unresponsive to fluid replacement and vasopressor therapy.
机译：败血性休克是美国第13大死亡原因。严重的败血症发生率在2003年结束的10年中几乎翻了一番，死亡率增加了60％以上。系统性炎症反应综合征具有非感染性和感染性原因。非感染性疾病包括烧伤，创伤，严重胰腺炎，以及单克隆抗体或免疫调节药物（如白介素2）的治疗。败血症综合征到败血性休克的发展是由一系列免疫反应引起的。随着感染性损伤的发展，凝血，免疫和应激反应系统的宿主随之激活，从而导致组织灌注不足和器官衰竭。对少量患者进行的早期研究表明，低剂量皮质类固醇激素的治疗​​对逆转休克，免疫系统和血液动力学特征具有明显的有益作用。低剂量皮质类固醇只应给予败血性休克的一部分患者，这些患者对补液和升压药物治疗无反应。

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