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首页> 外文期刊>Critical care medicine >Extents of white matter lesions and increased intraventricular extension of intracerebral hemorrhage
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Extents of white matter lesions and increased intraventricular extension of intracerebral hemorrhage

机译：白质病变的程度和脑出血的脑室内扩展增加

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OBJECTIVES: To determine whether the extent of white matter lesions on a CT scan of acute intracerebral hemorrhage patients is associated with the prevalence and severity of intraventricular extension of hemorrhage. DESIGN AND SETTING: A post hoc analysis of Acute Brain Bleeding Analysis-IntraCerebral Hemorrhage cohort, a nationwide prospective cohort of acute intracerebral hemorrhage patients (total number of cohort subjects, 1,604). PATIENTS: Spontaneous intracerebral hemorrhage patients (n = 1,262). INTERVENTIONS: None. MEASUREMENTS: The authors analyzed CT scan images taken within 48 hours after stroke onset. Extent of white matter lesions, volume of intracerebral hemorrhage, presence of intraventricular extension of hemorrhage, and intraventricular extension of hemorrhage score (approximation of intraventricular extension of hemorrhage volume) were measured using CT scans, and demographic, laboratory, clinical, and mortality data were also gathered through review of medical records and retrieval from the governmental statistical archive. MAIN RESULTS: The frequency of intraventricular extension of hemorrhage in our population was 27.2% (343 subjects). The proportion of extensive white matter lesions in intraventricular extension of hemorrhage subjects (33.8%) was higher than that of non-intraventricular extension of hemorrhage cases (16.3%; p < 0.01). Multivariable analysis showed that mild (odds ratio, 1.48; 95% confidence interval 1.05-0.09; p < 0.01) and extensive (odds ratio, 2.73; 95% confidence interval 1.88-3.98; p < 0.01) white matter lesions were significantly associated with the presence of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage patients. The estimated mean of the intraventricular extension of hemorrhage score from the extensive white matter lesions group (9.09 ± 0.76) was significantly higher than that of the no white matter lesions group (6.72 ± 0.78; p < 0.01 from analyses of covariances) after adjustment for relevant covariates. CONCLUSIONS: We documented that the severity of white matter lesions is related to the occurrence and amount of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage cases.
机译：目的：确定急性脑出血患者的CT扫描中白质病变的程度是否与脑室内出血的发生率和严重程度有关。设计与地点：急性脑出血分析-脑内出血队列的事后分析，这是一项全国性的急性脑出血患者的前瞻性队列（队列对象总数1,604）。患者：自发性脑出血患者（n = 1,262）。干预措施：无。测量：作者分析了卒中发作后48小时内拍摄的CT扫描图像。使用CT扫描测量白质病变的程度，脑出血的量，脑室内出血的存在和脑室内出血的得分（脑室内出血量的近似），并通过人口统计学，实验室，临床和死亡数据进行测量还通过审查病历和从政府统计档案中检索来收集信息。主要结果：在我们的人群中，脑室内出血的频率为27.2％（343名受试者）。出血对象的脑室内扩大中广泛的白质病变的比例（33.8％）高于非脑室内出血病例的比例（16.3％; p <0.01）。多变量分析表明，轻度（奇数比为1.48; 95％置信区间为1.05-0.09; p <0.01）和广泛性（奇数比为2.73; 95％置信区间为1.88-3.98; p <0.01）与白质病变显着相关自发性脑出血患者脑室内出血的存在。校正后，广泛白质病变组的脑室内出血评分的估计平均值（9.09±0.76）显着高于无白质病变组的脑室内出血评分的平均值（6.72±0.78; p <0.01）。相关协变量。结论：我们记录了自发性脑出血病例中白质病变的严重程度与出血的发生率和脑室内扩大量有关。

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