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A microsphere coupler for a nanowire waveguide plasmonic probe for molecular imaging

机译:用于分子成像的纳米线波导等离子体激元探针的微球耦合器

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Highly forward scattering of light by a silica microsphere is predicted by Mie theory. Finite-difference time-domain simulations are used to examine the use of a silica microsphere for coupling light into a ZnO nanowire terminated with a gold nanoparticle (NP) tip, intended for near-field imaging of single molecules immobilized on a gold substrate or gold nanoparticle-labeled cell membranes. The results show that plasmonic coupling at the Au tip is dependent on the incident angle of the excitation. Pre-conditioning the signal with the microsphere amplifies the coupling while reducing background energy levels, significantly boosting the signal-to-noise ratio.
机译:Mie理论预测了二氧化硅微球对光的高度前向散射。有限差分时域仿真用于检查使用二氧化硅微球将光耦合到以金纳米颗粒(NP)尖端终止的ZnO纳米线中的目的,旨在对固定在金基质或金上的单个分子进行近场成像。纳米颗粒标记的细胞膜。结果表明,Au尖端的等离子体耦合取决于激发的入射角。用微球对信号进行预处理可在降低背景能量水平的同时放大耦合,从而显着提高信噪比。

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