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首页> 外文期刊>Nanotechnology >Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure
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Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure

机译：全身暴露后，非晶态纳米二氧化硅诱发消耗性凝血病

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摘要

We previously reported that well-dispersed amorphous nanosilicas with particle size 70nm (nSP70) penetrate skin and produce systemic exposure after topical application. These findings underscore the need to examine biological effects after systemic exposure to nanosilicas. The present study was designed to examine the biological effects. BALB/c mice were intravenously injected with amorphous nanosilicas of sizes 70, 100, 300, 1000nm and then assessed for survival, blood biochemistry, and coagulation. As a result, injection of nSP70 caused fatal toxicity, liver damage, and platelet depletion, suggesting that nSP70 caused consumptive coagulopathy. Additionally, nSP70 exerts procoagulant activity in vitro associated with an increase in specific surface area, which increases as diameter reduces. In contrast, nSP70-mediated procoagulant activity was absent in factor XII-deficient plasma. Collectively, we revealed that interaction between nSP70 and intrinsic coagulation factors such as factor XII, were deeply related to nSP70-induced harmful effects. In other words, it is suggested that if interaction between nSP70 and coagulation factors can be suppressed, nSP70-induced harmful effects may be avoided. These results would provide useful information for ensuring the safety of nanomaterials (NMs) and open new frontiers in biological fields by the use of NMs.
机译：我们以前曾报道，局部应用后，粒径为70nm（nSP70）的分散良好的非晶态纳米二氧化硅会渗透皮肤并产生全身性暴露。这些发现强调了在全身性暴露于纳米二氧化硅后需要检查生物学效应的必要性。本研究旨在检查生物学效应。向BALB / c小鼠静脉内注射70、100、300、1000nm大小的无定形纳米二氧化硅，然后评估其存活率，血液生物化学和凝血功能。结果，注射nSP70会导致致命的毒性，肝脏损害和血小板减少，提示nSP70会引起消耗性凝血病。另外，nSP70在体外具有促凝活性，与比表面积的增加有关，比表面积的增加随直径的减小而增加。相反，在因子XII缺乏的血浆中不存在nSP70介导的促凝活性。总的来说，我们揭示了nSP70与内在凝血因子（例如XII因子）之间的相互作用与nSP70诱导的有害作用密切相关。换句话说，建议如果可以抑制nSP70与凝血因子之间的相互作用，则可以避免nSP70诱导的有害作用。这些结果将为确保纳米材料（NMs）的安全性提供有用的信息，并通过使用NMs开辟生物领域的新领域。

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