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Magnetic anisotropy considerations in magnetic force microscopy studies of single superparamagnetic nanoparticles

机译：单个超顺磁性纳米粒子的磁力显微镜研究中的磁各向异性注意事项

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摘要

In recent years, superparamagnetic nanoparticles (SPNs) have become increasingly important in applications ranging from solid state memory devices to biomedical diagnostic and therapeutic tools. However, detection and characterization of the small and unstable magnetic moment of an SPN at the single particle level remains a challenge. Further, depending on their physical shape, crystalline structure or orientation, SPNs may also possess magnetic anisotropy, which can govern the extent to which their magnetic moments can align with an externally applied magnetic field. Here, we demonstrate how we can exploit the magnetic anisotropy of SPNs to enable uniform, highly-sensitive detection of single SPNs using magnetic force microscopy (MFM) in ambient air. Superconducting quantum interference device magnetometry and analytical transmission electron microscopy techniques are utilized to characterize the collective magnetic behavior, morphology and composition of the SPNs. Our results show how the consideration of magnetic anisotropy can enhance the ability of MFM to detect single SPNs at ambient room temperature with high force sensitivity and spatial resolution.
机译：近年来，超顺磁性纳米粒子（SPN）在从固态存储设备到生物医学诊断和治疗工具的应用中变得越来越重要。然而，在单个粒子水平上检测和表征SPN的小而不稳定的磁矩仍然是一个挑战。此外，取决于其物理形状，晶体结构或取向，SPN还可以具有磁各向异性，这可以控制其磁矩可以与外部施加的磁场对齐的程度。在这里，我们演示了如何利用环境空气中的磁力显微镜（MFM）来利用SPN的磁各向异性来实现单个SPN的均匀，高灵敏度检测。利用超导量子干涉仪的磁力测定和透射电子显微镜分析技术来表征SPN的集体磁行为，形态和组成。我们的结果表明，磁各向异性的考虑如何以较高的力敏感度和空间分辨率增强MFM在室温下检测单个SPN的能力。

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