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Functionalized polymer spheres via one-step photoinduced synthesis for antimicrobial activity and gene delivery

机译：通过一步光诱导合成功能化的聚合物球，用于抗菌活性和基因传递

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摘要

Despite the fact that polystyrene (PS) spheres have been developed as polymeric carriers or matrices for various biomedical applications, the synthesis of PS spheres is time-consuming. This work describes the fabrication of a uniform PS sphere, coated with silver nanoparticles (AgPS), by simultaneous photoinduced polymerization and reduction fabricated using x-rays in aqueous solution without any initiator. The solution contains only styrene, silver ions (Ag ~+), and poly(vinyl pyrrolidone) (PVP) as a stabilizer. The proposed mechanism of the formation of the AgPS nanocomposite spheres involves the generation of radicals in the aqueous solution to induce PS polymerization and the reduction of Ag. The distribution of the sizes of the core PS spheres in the AgPS nanocomposite spheres was systematically examined as a function of irradiation time, concentration of styrene, and amount of PVP. AgPS nanocomposite spheres exhibit antimicrobial activity against bacteria (Escherichia coli and Staphylococcus aureus). Additionally, the cationic (vinylbenzyl)trimethylammonium (TMA) monomer was photopolymerized to form positively charged TMAPS spheres as gene carriers with uniquely low cytotoxicity. Given these design advantages, the method proposed herein is simpler than typical approaches for synthesizing PS spheres with functionalized groups and PS spheres coated with Ag nanoparticles.
机译：尽管已经开发了聚苯乙烯（PS）球作为各种生物医学应用的聚合物载体或基质，但PS球的合成非常耗时。这项工作描述了在不使用任何引发剂的情况下，通过在水溶液中使用X射线同时进行光诱导聚合和还原来制备均匀涂布有银纳米颗粒（AgPS）的PS球的方法。该溶液仅包含苯乙烯，银离子（Ag〜+）和聚（乙烯基吡咯烷酮）（PVP）作为稳定剂。提出的形成AgPS纳米复合球的机理涉及在水溶液中产生自由基以诱导PS聚合和Ag的还原。系统地检查了AgPS纳米复合球中核心PS球尺寸的分布与辐照时间，苯乙烯浓度和PVP量的关系。 AgPS纳米复合材料球体对细菌（大肠杆菌和金黄色葡萄球菌）具有抗菌活性。此外，将阳离子（乙烯基苄基）三甲基铵（TMA）单体进行光聚合，以形成带正电的TMAPS球体作为具有极低细胞毒性的基因载体。鉴于这些设计优势，本文提出的方法比合成具有官能团的PS球和涂有Ag纳米粒子的PS球的典型方法更简单。

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