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Quantification of magnetic nanoparticles with low frequency magnetic fields: Compensating for relaxation effects

机译：具有低频磁场的磁性纳米粒子的定量：补偿弛豫效应

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摘要

Quantifying the number of nanoparticles present in tissue is central to many in vivo and in vitro applications. Magnetic nanoparticles can be detected with high sensitivity both in vivo and in vitro using the harmonics of their magnetization produced in a sinusoidal magnetic field. However, relaxation effects damp the magnetic harmonics rendering them of limited use in quantification. We show that an accurate measure of the number of nanoparticles can be made by correcting for relaxation effects. Correction for relaxation reduced errors of 50% for larger nanoparticles in high relaxation environments to 2%. The result is a method of nanoparticle quantification suitable for in vivo and in vitro applications including histopathology assays, quantitative imaging, drug delivery and thermal therapy preparation.
机译：量化组织中存在的纳米颗粒的数量对于许多体内和体外应用都是至关重要的。使用正弦磁场中产生的磁化谐波，可以在体内和体外高灵敏度地检测磁性纳米粒子。但是，弛豫效应会抑制电磁谐波，从而使其在定量中的使用受到限制。我们表明，可以通过校正松弛效应来精确测量纳米颗粒的数量。弛豫校正将高弛豫环境中较大纳米颗粒的误差降低了50％，降至2％。结果是一种适用于体内和体外应用的纳米颗粒定量方法，包括组织病理学测定，定量成像，药物递送和热疗法制备。

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