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首页> 外文期刊>Nanotechnology >Ingestion of gallium phosphide nanowires has no adverse effect on Drosophila tissue function
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Ingestion of gallium phosphide nanowires has no adverse effect on Drosophila tissue function

机译：摄入磷化镓纳米线对果蝇的组织功能没有不利影响

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摘要

Engineered nanoparticles have been under increasing scrutiny in recent years. High aspect ratio nanoparticles such as carbon nanotubes and nanowires have raised safety concerns due to their geometrical similarity to asbestos fibers. III-V epitaxial semiconductor nanowires are expected to be utilized in devices such as LEDs and solar cells and will thus be available to the public. In addition, clean-room staff fabricating and characterizing the nanowires are at risk of exposure, emphasizing the importance of investigating their possible toxicity. Here we investigated the effects of gallium phosphide nanowires on the fruit fly Drosophila melanogaster. Drosophila larvae and/or adults were exposed to gallium phosphide nanowires by ingestion with food. The toxicity and tissue interaction of the nanowires was evaluated by investigating tissue distribution, activation of immune response, genome-wide gene expression, life span, fecundity and somatic mutation rates. Our results show that gallium phosphide nanowires applied through the diet are not taken up into Drosophila tissues, do not elicit a measurable immune response or changes in genome-wide gene expression and do not significantly affect life span or somatic mutation rate.
机译：近年来，工程纳米颗粒受到越来越严格的审查。高纵横比的纳米颗粒（例如碳纳米管和纳米线）由于其与石棉纤维的几何相似性而引起了安全问题。 III-V外延半导体纳米线有望在LED和太阳能电池等设备中使用，因此将向公众提供。此外，制造和表征纳米线的无尘室工作人员有暴露的风险，强调研究其可能毒性的重要性。在这里，我们研究了磷化镓纳米线对果蝇果蝇的影响。果蝇幼虫和/或成虫通过食物摄入而暴露于磷化镓纳米线。通过研究组织分布，免疫应答的激活，全基因组基因表达，寿命，繁殖力和体细胞突变率来评估纳米线的毒性和组织相互作用。我们的结果表明，饮食中施用的磷化镓纳米线不会被摄入果蝇组织中，不会引起可测量的免疫反应或全基因组基因表达的变化，并且不会显着影响寿命或体细胞突变率。

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