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Rapid microwave-assisted synthesis of dextran-coated iron oxide nanoparticles for magnetic resonance imaging

机译：微波辅助快速合成葡聚糖包覆的氧化铁纳米粒子用于磁共振成像

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Currently, magnetic iron oxide nanoparticles are the only nanosized magnetic resonance imaging (MRI) contrast agents approved for clinical use, yet commercial manufacturing of these agents has been limited or discontinued. Though there is still widespread demand for these particles both for clinical use and research, they are difficult to obtain commercially, and complicated syntheses make in-house preparation unfeasible for most biological research labs or clinics. To make commercial production viable and increase accessibility of these products, it is crucial to develop simple, rapid and reproducible preparations of biocompatible iron oxide nanoparticles. Here, we report a rapid, straightforward microwave-assisted synthesis of superparamagnetic dextran-coated iron oxide nanoparticles. The nanoparticles were produced in two hydrodynamic sizes with differing core morphologies by varying the synthetic method as either a two-step or single-step process. A striking benefit of these methods is the ability to obtain swift and consistent results without the necessity for air-, pH- or temperature-sensitive techniques; therefore, reaction times and complex manufacturing processes are greatly reduced as compared to conventional synthetic methods. This is a great benefit for cost-effective translation to commercial production. The nanoparticles are found to be superparamagnetic and exhibit properties consistent for use in MRI. In addition, the dextran coating imparts the water solubility and biocompatibility necessary for in vivo utilization.
机译：当前，磁性氧化铁纳米颗粒是唯一被批准用于临床的纳米级磁共振成像（MRI）造影剂，但是这些试剂的商业生产受到限制或中止。尽管对这些颗粒的临床用途和研究仍存在着广泛的需求，但它们很难在商业上获得，而且复杂的合成方法使得大多数生物学研究实验室或诊所无法进行内部制备。为了使商业生产可行并增加这些产品的可及性，开发简单，快速且可重现的生物相容性氧化铁纳米颗粒制剂至关重要。在这里，我们报告了一种快速，直接的微波辅助合成的超顺磁性葡聚糖包被的氧化铁纳米粒子。通过改变合成方法为两步法或单步法，纳米颗粒以两种流体力学尺寸生产，具有不同的核心形态。这些方法的显着优势是无需空气，pH或温度敏感技术即可获得快速一致的结果的能力。因此，与传统的合成方法相比，反应时间和复杂的制造工艺大大减少了。这是将成本效益高的翻译成商业产品的巨大好处。发现纳米粒子是超顺磁性的，并且表现出与用于MRI中一致的性质。另外，右旋糖酐涂层赋予体内利用所必需的水溶性和生物相容性。

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