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On-substrate fabrication of a bio-conjugated Au nanoring solution for photothermal therapy application

机译:在基板上制造用于光热疗法的生物共轭金纳米环溶液

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摘要

The on-substrate fabrication of a bio-conjugated Au nanoring (NRI) solution with the localized surface plasmon (LSP) resonance wavelength in the 1200-1300 nm range is demonstrated. Also, the effects of photothermal therapy through LSP resonance-induced absorption enhancement are illustrated by applying the bio-conjugated Au NRIs to human liver cancer cells and illuminating the cells with a laser of 1315 nm in wavelength. The Au NRI fabrication is based on the techniques of nano-imprint lithography and metal secondary sputtering. The procedure for on-substrate surface modification of Au NRIs leads to a high production yield of bio-conjugated NRIs. The threshold levels of the local laser intensity for injuring cancer cells based on the LSP resonances of Au NRIs of two different samples are determined.
机译:演示了在衬底上制造的生物共轭金纳米环(NRI)溶液,其局部表面等离子体激元(LSP)共振波长在1200-1300 nm范围内。此外,通过将生物共轭的金型NRI应用于人肝癌细胞并用波长为1315 nm的激光照射细胞,可以说明通过LSP共振诱导的吸收增强而进行的光热疗法的效果。 Au NRI的制造基于纳米压印光刻技术和金属二次溅射技术。用于Au NRI的衬底上表面改性的方法导致生物共轭NRI的高产率。基于两个不同样品的Au NRI的LSP共振,确定用于损伤癌细胞的局部激光强度的阈值水平。

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