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Engineering Gd-loaded nanoparticles to enhance MRI sensitivity via T_1 shortening

机译：工程化Gd负载的纳米颗粒，通过缩短T_1来增强MRI敏感性

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摘要

Magnetic resonance imaging (MRI) is a noninvasive imaging technique capable of obtaining high-resolution anatomical images of the body. Major drawbacks of MRI are the low contrast agent sensitivity and inability to distinguish healthy tissue from diseased tissue, making early detection challenging. To address this technological hurdle, paramagnetic contrast agents have been developed to increase the longitudinal relaxivity, leading to an increased signal-to-noise ratio. This review focuses on methods and principles that enabled the design and engineering of nanoparticles to deliver contrast agents with enhanced ionic relaxivities. Different engineering strategies and nanoparticle platforms will be compared in terms of their manufacturability, biocompatibility properties, and their overall potential to make an impact in clinical MR imaging.
机译：磁共振成像（MRI）是一种无创成像技术，能够获取人体的高分辨率解剖图像。 MRI的主要缺点是造影剂灵敏度低以及无法区分健康组织和患病组织，这给早期检测带来了挑战。为了解决该技术障碍，已经开发了顺磁性造影剂以增加纵向弛豫性，从而导致信噪比增加。这篇综述集中于使纳米颗粒的设计和工程化能够提供具有增强的离子弛豫性的造影剂的方法和原理。将根据其可制造性，生物相容性特性以及对临床MR成像产生影响的总体潜力，对不同的工程策略和纳米颗粒平台进行比较。

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