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Understanding magnetic nanoparticle osteoblast receptor-mediated endocytosis using experiments and modeling

机译：使用实验和建模了解磁性纳米颗粒成骨细胞受体介导的内吞作用

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摘要

Iron oxide nanoparticles are promising candidates for controlling drug delivery through an external magnetic force to treat a wide range of diseases, including osteoporosis. Previous studies have demonstrated that in the presence of hydroxyapatite coated magnetite (Fe3O4) nanoparticles, osteoblast (or bone forming cell) proliferation and long-term functions (such as calcium deposition) were significantly enhanced. Hydroxyapatite is the major inorganic component of bone. As a further attempt to understand why, in the current study, the uptake of such nanoparticles into osteoblasts was experimentally investigated and mathematically modeled. Magnetite nanoparticles were synthesized using a co-precipitation method and were coated with hydroxyapatite. A cellular uptake experiment at low temperatures indicated that receptor-mediated endocytosis contributed to the internalization of the magnetic nanoparticles into osteoblasts. A model was further developed to explain the uptake of magnetic nanoparticles into osteoblasts using receptor-mediated endocytosis. This model may explain the internalization of hydroxyapatite into osteoblasts to elevate intracellular calcium levels necessary to promote osteoblast functions to treat a wide range of orthopedic problems, including osteoporosis.
机译：氧化铁纳米粒子是有望通过外部磁力控制药物输送的候选药物，以治疗包括骨质疏松症在内的各种疾病。先前的研究表明，在羟基磷灰石涂层的磁铁矿（Fe3O4）纳米粒子的存在下，成骨细胞（或骨形成细胞）的增殖和长期功能（例如钙沉积）得到了显着增强。羟基磷灰石是骨骼的主要无机成分。为了进一步理解为什么在当前的研究中，对这种纳米颗粒对成骨细胞的摄取进行了实验研究和数学建模。使用共沉淀法合成磁铁矿纳米颗粒，并用羟基磷灰石包被。低温下的细胞摄取实验表明，受体介导的内吞作用有助于磁性纳米颗粒内化为成骨细胞。进一步开发了一个模型来解释使用受体介导的内吞作用将磁性纳米颗粒吸收到成骨细胞中。该模型可能解释了羟基磷灰石进入成骨细胞的内在化，从而提高了促进成骨细胞功能以治疗包括骨质疏松症在内的各种骨科疾病所必需的细胞内钙水平。

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