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首页> 外文期刊>Nanotechnology >The anti-hepatoma effect of nanosized Mn-Zn ferrite magnetic fluid hyperthermia associated with radiation in vitro and in vivo
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The anti-hepatoma effect of nanosized Mn-Zn ferrite magnetic fluid hyperthermia associated with radiation in vitro and in vivo

机译：纳米锰锌铁氧体磁流体热疗在体外和体内的抗肝癌作用

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Joint therapy is a promising area of study in cancer treatment. In this paper, we prepared Mn-Zn ferrite (Mn_(0.5)Zn_(0.5)Fe_(2O)4) magnetofluid using PEI as a surfactant, and investigated the anticancer effect of Mn_(0.5)Zn_(0.5)Fe_(2O)4 magnetic fluid hyperthermia (MFH) combined with radiotherapy on hepatocellular carcinoma. Both in vitro and in vivo results suggest that this combined treatment with MFH and radiation has a better therapeutic effect than either of them alone. The apoptotic rate and necrotic rate of the combined treatment group was 38.80 and 25.20%, respectively. In contrast, it was only 7.49 and 3.62% in the radiation-alone group, 15.23 and 7.90% in the MFH-alone group, only 3.52 and 2.16% in the blank control group, and 23.56 and 27.56% in the adriamycin group. The cell proliferation inhibition rate of the combined treatment group (88.5%) was significantly higher than that of the radiation-alone group (37.5%), MFH-alone group (60.6%) and adriamycin group (70.6%). The tumor volume inhibition and mass inhibition rate of the combined treatment group was 87.62 and 88.62%, respectively, obviously higher than the 41.04 and 34.20% of the radiation-alone group, 79.87 and 77.92% of the MFH-alone group and 71.76 and 66.87% of the adriamycin group. It is therefore concluded that this combined application of MFH and radiation can give good synergistic and complementary effects, which offers a viable approach for treatment of cancer.
机译：联合疗法是癌症治疗中一个有前途的研究领域。本文以PEI为表面活性剂制备了Mn-Zn铁氧体（Mn_（0.5）Zn_（0.5）Fe_（2O）4）磁流体，并研究了Mn_（0.5）Zn_（0.5）Fe_（2O）的抗癌作用。 4磁流体热疗（MFH）联合放疗治疗肝细胞癌。体外和体内结果均表明，与MFH和放射线联合使用比单独使用两者具有更好的治疗效果。联合治疗组的凋亡率和坏死率分别为38.80％和25.20％。相比之下，仅放疗组分别为7.49％和3.62％，仅放疗组为15.23％和7.90％，空白对照组仅为3.52％和2.16％，阿霉素组分别为23.56％和27.56％。联合治疗组的细胞增殖抑制率（88.5％）明显高于单纯放疗组（37.5％），单纯MFH组（60.6％）和阿霉素组（70.6％）。联合治疗组的肿瘤体积抑制率和质量抑制率分别为87.62％和88.62％，明显高于单纯放疗组的41.04％和34.20％，仅单纯MFH组的79.87％和77.92％以及单纯放疗组的71.76％和66.87％。阿霉素组的百分比。因此，可以得出结论，MFH和放射线的这种联合应用可以产生良好的协同和互补作用，这为癌症的治疗提供了可行的方法。

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