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首页> 外文期刊>Nanotechnology >Preparation of non-aggregating aqueous fullerenes in highly saline solutions with a biocompatible non-ionic polymer
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Preparation of non-aggregating aqueous fullerenes in highly saline solutions with a biocompatible non-ionic polymer

机译：使用生物相容性非离子聚合物在高盐溶液中制备非聚集性富勒烯水溶液

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摘要

Size-tunable stable aqueous fullerenes were prepared with different concentrations of biocompatible block-copolymer pluronic (PA) F-127, ranging from 0.001% to 1% (w/v). Size uniformity increased with the increase in PA concentration, yielding optimum 58.8 ± 5.6 and 61.8 ± 5.6 nm nC_(60)s and nC_(70)s, respectively (0.10%w/v PA), as observed using a dynamic light scattering technique. Fullerene aqueous suspensions also manifested enhanced stability in saline solution, Dulbecco's modified Eagle medium (DMEM), and Roswell Park Memorial Institute (RPMI) culture medium. Transmission electron microscopy was performed to elaborate on the morphology and size specificity of fullerene clusters. Physicochemical characterizations of the suspended fullerenes were performed through UV-vis spectroscopy and electrophoretic mobility measurements. PA molecules showed size restriction by encasement, as observed via molecular dynamics simulations. Such solubilization with controllable size and non-aggregating behavior can facilitate application enhancement and mechanistic environmental and toxicological studies of size-specific fullerenes.
机译：用不同浓度的生物相容性嵌段共聚物普朗尼克（PA）F-127制备尺寸可调的稳定富勒烯水溶液，其浓度范围为0.001％至1％（w / v）。尺寸均匀性随PA浓度的增加而增加，如使用动态光散射技术观察到的，分别产生最佳58.8±5.6和61.8±5.6 nm nC_（60）s和nC_（70）s（0.10％w / v PA）。 。富勒烯水悬浮液在盐溶液，Dulbecco改良的Eagle培养基（DMEM）和Roswell Park Memorial Institute（RPMI）培养基中也表现出增强的稳定性。进行透射电子显微镜以详细说明富勒烯簇的形态和尺寸特异性。悬浮的富勒烯的理化特性通过紫外可见光谱和电泳迁移率测量进行。 PA分子通过包裹表现出尺寸限制，如通过分子动力学模拟观察到的。具有可控制的尺寸和非聚集行为的这种增溶作用可促进尺寸特定的富勒烯的应用增强以及机械的环境和毒理学研究。

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