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首页> 外文期刊>Nanotechnology >Colloidal stability and thermo-responsive properties of iron oxide nanoparticles coated with polymers: Advantages of Pluronic? F68-PEG mixture
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Colloidal stability and thermo-responsive properties of iron oxide nanoparticles coated with polymers: Advantages of Pluronic? F68-PEG mixture

机译：涂有聚合物的氧化铁纳米粒子的胶体稳定性和热响应特性：Pluronic？的优势F68-PEG混合物

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Superparamagnetic iron oxide nanoparticles (SPIONs) are recognized to be an attractive platform for developing novel drug delivery approaches and thus several types of functionalized magnetic nanocarriers based on SPIONs have been synthesized and studied. The coating of the metal oxide surface was achieved in a one-pot synthesis with biocompatible polyethylene glycol (PEG) and thermo-responsive modified Pluronic? F68. The resulting thermo-responsive magnetic nanocarriers can incorporate water insoluble drugs into their hydrophobic compartment and later release them in a temperature dependent manner. Here we report novel magnetic nanocarriers with significant improvements regarding the colloidal stability and critical temperature obtained by mixing various molar ratios of hydrophilic PEG with thermo-responsive Pluronic? F68 bearing different end group functionalities. Various methods have been employed to characterize the magnetic nanocarriers, such as photon correlation spectroscopy (DLS), atomic absorption, FT-IR spectroscopy, and surface-enhanced Raman scattering. The transition temperature that determines changes in the conformation of the block copolymer chain was studied by DLS as a function of temperature. Moreover, the drug loading properties of SPION-(F68-OMe)-(F68-FA) and SPION-PEG-F68-FA were analyzed with a hydrophobic fluorescent dye, DID oil. The behavior of the encapsulated DID into the nanocarrier shell was studied as a function of temperature via fluorescence spectroscopy. These results offer original insights into the enhanced colloidal stability and thermo-sensitive properties of the novel synthesized magnetic nanocarriers.
机译：超顺磁性氧化铁纳米颗粒（SPIONs）被认为是开发新型药物递送方法的有吸引力的平台，因此已经合成和研究了几种基于SPIONs的功能化磁性纳米载体。用生物相容性聚乙二醇（PEG）和热响应性改性的Pluronic？一锅法合成金属氧化物表面的涂层。 F68。所得的热响应性磁性纳米载体可以将水不溶性药物掺入其疏水区室中，然后以温度依赖性方式释放它们。在这里，我们报告了新型磁性纳米载体，该纳米载体通过将各种摩尔比的亲水性PEG与热响应性Pluronic？混合而获得的胶体稳定性和临界温度有了显着改善。 F68具有不同的端基功能。已经采用了各种方法来表征磁性纳米载体，例如光子相关光谱（DLS），原子吸收，FT-IR光谱和表面增强拉曼散射。通过DLS研究了决定嵌段共聚物链构象变化的转变温度与温度的关系。此外，用疏水性荧光染料DID油分析了SPION-（F68-OMe）-（F68-FA）和SPION-PEG-F68-FA的载药特性。通过荧光光谱研究了封装到纳米载体壳中的DID的行为与温度的关系。这些结果为新型合成磁性纳米载体的增强的胶体稳定性和热敏性质提供了独到的见解。

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