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首页> 外文期刊>Nanotechnology >Functionalized graphene oxide-based thermosensitive hydrogel for magnetic hyperthermia therapy on tumors
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Functionalized graphene oxide-based thermosensitive hydrogel for magnetic hyperthermia therapy on tumors

机译：功能化的基于氧化石墨烯的热敏水凝胶，用于肿瘤的磁热疗

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摘要

A novel locally injectable, biodegradable, and thermo-sensitive hydrogel made from chitosan and beta-glycerophosphate salt was prepared. It incorporated polyethylenimine (PEI)-modified super-paramagnetic graphene oxide (GO/IONP/PEI) as a form of minimally invasive treatment of cancer lesions by magnetically induced local hyperthermia. Doxorubicin (DOX) was mixed into the hydrogel which was pre-loaded on GO/IONP/PEI to create a drug delivery system DOX-GO/IONP/PEI-gel. In addition to the evaluation of in vitro and in vivo antitumor activities, the physicochemical properties, magnetic properties and DOX release profile of the DOX-GO/IONP/PEI-gel were determined. The aqueous solution of the hydrogel showed a solgel transition behavior depending on temperature changes. Magnetization loops indicated the super-paramagnetic properties of GO/IONP/PEI. Compared with free DOX, DOX-GO/IONP/PEI could efficiently pass through cell membranes, leading to more apoptosis and demonstrating higher antitumor efficacy on MCF-7 cells in vitro. Furthermore, DOX-GO/IONP/PEI-gel intratumorally injected (i.t.) showed high antitumor efficacy on tumor-bearing mice in vivo, with no obvious toxicity. The antitumor efficacy was higher when combined with an alternating magnetic field (AMF), showing that DOX-GO/IONP/PEI-gel under AMF has great potential for cancer magnetic hyperthermia therapy.
机译：制备了由壳聚糖和β-甘油磷酸盐制成的新型局部可注射，可生物降解和热敏水凝胶。它并入了聚乙烯亚胺（PEI）改性的超顺磁性氧化石墨烯（GO / IONP / PEI），作为通过磁诱导的局部热疗对癌症病变进行微创治疗的一种形式。将阿霉素（DOX）混合到水凝胶中，将其预先加载在GO / IONP / PEI上以创建药物递送系统DOX-GO / IONP / PEI-gel。除了评估体外和体内抗肿瘤活性外，还测定了DOX-GO / IONP / PEI-gel的理化性质，磁性和DOX释放曲线。水凝胶的水溶液显示出取决于温度变化的溶胶凝胶转变行为。磁化回路表明GO / IONP / PEI的超顺磁性。与游离DOX相比，DOX-GO / IONP / PEI可以有效地穿过细胞膜，从而导致更多的细胞凋亡并在体外对MCF-7细胞显示出更高的抗肿瘤功效。此外，肿瘤内注射的DOX-GO / IONP / PEI-凝胶（i.t.）在体内对荷瘤小鼠显示出高的抗肿瘤功效，没有明显的毒性。当与交变磁场（AMF）结合使用时，抗肿瘤功效更高，这表明在AMF下使用DOX-GO / IONP / PEI-gel具有巨大的癌症磁热疗潜力。

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