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Comparison of the magnetic, radiolabeling, hyperthermic and biodistribution properties of hybrid nanoparticles bearing CoFe_2O_4 and Fe_3O_4 metal cores

机译:带有CoFe_2O_4和Fe_3O_4金属核的杂化纳米粒子的磁性,放射性标记,高温和生物分布特性的比较

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摘要

Metal oxide nanoparticles, hybridized with various polymeric chemicals, represent a novel and breakthrough application in drug delivery, hyperthermia treatment and imaging techniques. Radiolabeling of these nanoformulations can result in new and attractive dual-imaging agents as well as provide accurate in vivo information on their biodistribution profile. In this paper a comparison study has been made between two of the most promising hybrid core-shell nanosystems, bearing either magnetite .Fe_3O_4/ or cobalt ferrite .CoFe_2O_4/ cores, regarding their magnetic, radiolabeling, hyperthermic and biodistribution properties. While hyperthermic properties were found to be affected by the metal-core type, the radiolabeling ability and the in vivo fate of the nanoformulations seem to depend critically on the size and the shell composition.
机译:金属氧化物纳米粒子,与各种高分子化学物质杂交,代表了药物输送,热疗和成像技术中的一种新颖且突破性的应用。这些纳米制剂的放射性标记可产生新颖且有吸引力的双成像剂,并提供有关其生物分布特征的准确体内信息。在本文中,已经对两个最有希望的混合磁-壳纳米系统进行了比较研究,它们分别具有磁铁矿.Fe_3O_4 /或钴铁氧体.CoFe_2O_4 /核,具有磁性,放射性标记,高温和生物分布特性。虽然发现高温性质受金属核类型的影响,但纳米制剂的放射性标记能力和体内命运似乎主要取决于大小和壳的组成。

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