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Magnetic particle hyperthermia -a promising tumour therapy?

机译：磁粉热疗-一种有希望的肿瘤治疗方法？

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摘要

We present a critical review of the state of the art of magnetic particle hyperthermia (MPH) as a minimal invasive tumour therapy. Magnetic principles of heating mechanisms are discussed with respect to the optimum choice of nanoparticle properties. In particular, the relation between superparamagnetic and ferrimagnetic single domain nanoparticles is clarified in order to choose the appropriate particle size distribution and the role of particle mobility for the relaxation path is discussed. Knowledge of the effect of particle properties for achieving high specific heating power provides necessary guidelines for development of nanoparticles tailored for tumour therapy. Nanoscale heat transfer processes are discussed with respect to the achievable temperature increase in cancer cells. The need to realize a well-controlled temperature distribution in tumour tissue represents the most serious problem of MPH, at present. Visionary concepts of particle administration, in particular by means of antibody targeting, are far from clinical practice, yet. On the basis of current knowledge of treating cancer by thermal damaging, this article elucidates possibilities, prospects, and challenges for establishment of MPH as a standard medical procedure.
机译：我们提出了磁粉热疗（MPH）技术作为微创肿瘤治疗技术的最新进展的重要评论。关于纳米颗粒性质的最佳选择，讨论了加热机理的磁性原理。特别是，阐明了超顺磁性和亚铁磁性单畴纳米粒子之间的关系，以便选择合适的粒径分布，并讨论了粒子迁移率对弛豫路径的作用。了解颗粒特性对实现高比热功率的影响，为开发适合肿瘤治疗的纳米颗粒提供了必要的指导。关于癌细胞中可达到的温度升高，讨论了纳米级传热过程。目前，需要在肿瘤组织中实现良好控制的温度分布是MPH最严重的问题。然而，尤其是通过抗体靶向的粒子施用的有远见的概念离临床实践还很远。根据当前通过热损伤治疗癌症的知识，本文阐明了将MPH确立为标准医疗程序的可能性，前景和挑战。

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