• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nanotechnology >Carrier-free, functionalized pure drug nanorods as a novel cancer-targeted drug delivery platform
【24h】

Carrier-free, functionalized pure drug nanorods as a novel cancer-targeted drug delivery platform

机译：无载体，功能化的纯药物纳米棒作为靶向癌症的新型药物递送平台

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A one-dimensional drug delivery system (1D DDS) is highly attractive since it has distinct advantages such as enhanced drug efficiency and better pharmacokinetics. However, drugs in 1D DDSs are all encapsulated in inert carriers, and problems such as low drug loading content and possible undesirable side effects caused by the carriers remain a serious challenge. In this paper, a novel, carrier-free, pure drug nanorod-based, tumor-targeted 1D DDS has been developed. Drugs are first prepared as nanorods and then surface functionalized to achieve excellent water dispersity and stability. The resulting drug nanorods show enhanced internalization rates mainly through energy-dependent endocytosis, with the shape-mediated nanorod (NR) diffusion process as a secondary pathway. The multiple endocytotic mechanisms lead to significantly improved drug efficiency of functionalized NRs with nearly ten times higher cytotoxicity than those of free molecules and unfunctionalized NRs. A targeted drug delivery system can be readily achieved through surface functionalization with targeting group linked amphipathic surfactant, which exhibits significantly enhanced drug efficacy and discriminates between cell lines with high selectivity. These results clearly show that this tumor-targeting DDS demonstrates high potential toward specific cancer cell lines.
机译：一维药物递送系统（1D DDS）具有很高的吸引力，因为它具有诸如提高药物效率和更好的药代动力学等独特优势。但是，一维DDS中的药物都被封装在惰性载体中，诸如低载药量以及由载体引起的可能的不良副作用等问题仍然是一个严峻的挑战。在本文中，开发了一种新颖的，无载体的，基于纯药物纳米棒的，靶向肿瘤的1D DDS。首先将药物制成纳米棒，然后将其表面官能化以实现出色的水分散性和稳定性。所得的药物纳米棒主要通过能量依赖的内吞作用表现出更高的内在化速率，其中形状介导的纳米棒（NR）扩散过程是次要途径。多种内吞机制导致功能性NRs的药物效率显着提高，其细胞毒性是游离分子和未功能化NRs的近十倍。通过靶向基团连接的两亲性表面活性剂的表面功能化，可以很容易地实现靶向药物递送系统，该表面官能团显示出显着增强的药物功效并且以高选择性区分细胞系。这些结果清楚地表明，这种靶向肿瘤的DDS对特定癌细胞系具有很高的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号