Fe3O4@ZnO core-shell nanocomposites for efficient and repetitive removal of low density lipoprotein in plasma and on blood vessel

Huang Xiao; Lu Juan; Yue Danyang; Fan Yijuan; Yi Caixia; Wang Xiaoying; Zhang Mengxue; Pan Jun

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Fe3O4@ZnO core-shell nanocomposites for efficient and repetitive removal of low density lipoprotein in plasma and on blood vessel

机译：Fe3O4 @ ZnO核壳纳米复合材料可有效，重复地去除血浆和血管中的低密度脂蛋白

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Low density lipoprotein (LDL)-apheresis therapy, which directly removes LDL from plasma by LDL-adsorbents in vitro is found to be clinically effective and safe to lower the LDL content in blood to prevent cardiovascular disease. Thus, developing excellent LDL adsorbents are becoming more and more attractive. Herein, functional Fe3O4@ZnO core-shell nanocomposites have been synthesized by a facile and eco-friendly two-step method. Not only do they possess high LDL adsorption (in PBS/plasma as well as on blood vessels) and favorable magnetic targeting ability but they can also be reused conveniently, which offer the Fe3O4@ZnO core-shell nanocomposites significant potential in the removal of LDL in vitro and in vivo.

机译：发现低密度脂蛋白（LDL）置换疗法可在体外通过LDL吸附剂直接从血浆中去除LDL，是临床有效且安全的降低血液中LDL含量以预防心血管疾病的方法。因此，开发优异的LDL吸附剂变得越来越有吸引力。在这里，功能性Fe3O4 @ ZnO核壳纳米复合材料已经通过一种简便且环保的两步法合成。它们不仅具有高的LDL吸附（在PBS /血浆中以及在血管上）和良好的磁性靶向能力，而且还可以方便地重复使用，这为Fe3O4 @ ZnO核壳纳米复合材料提供了去除LDL的巨大潜力。体外和体内。

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来源
《Nanotechnology》 |2015年第12期|共8页
作者
Huang Xiao; Lu Juan; Yue Danyang; Fan Yijuan; Yi Caixia; Wang Xiaoying; Zhang Mengxue; Pan Jun;
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正文语种 eng
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low density lipoprotein; Fe3O4@ZnO core-shell nanocomposites; reusable remover; magnetic targeting;

机译：低密度脂蛋白;Fe3O4 @ ZnO核壳纳米复合材料;可重复使用的去除剂;磁性靶向;

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1. Fe3O4@ZnO core-shell nanocomposites for efficient and repetitive removal of low density lipoprotein in plasma and on blood vessel [J] . Huang Xiao, Lu Juan, Yue Danyang, Nanotechnology . 2015,第12期

机译：Fe3O4 @ ZnO核壳纳米复合材料可有效，重复地去除血浆和血管中的低密度脂蛋白
2. Long-term effect of low-density lipoprotein apheresis on plasma lipoproteins and coronary heart disease in native vessels and coronary bypass in severe heterozygous familial hypercholesterolemia. [J] . Richter WO, Donner MG, Hofling B, Metabolism: Clinical and Experimental . 1998,第7期

机译：在严重的杂合性家族性高胆固醇血症中，低密度脂蛋白单采对血浆中脂蛋白和天然血管的冠心病以及冠状动脉搭桥术的长期影响。
3. Blood-pressure-reducing Effects of Anti-low-density Lipoprotein Cholesterol and Anti-hyperglycaemic Treatments in Patients with High Vascular Age for Chronological Age Can Blood Vessels Really be Rejuvenated ? [J] . Hiroo Tsuchida 新薬と臨牀 . 2014,第5期

机译：抗高密度脂蛋白胆固醇和抗高血糖治疗对按年龄分类的高血管年龄患者的血压降低效果能否使血管真正恢复活力？
4. Selective Removal Of Low-density Lipoproteins From Blood By Induced Precipitation With AAS [C] . Fang Bo, Jiang Tiqian '95 China-Korea conference on separation science and technology . 1995

机译：AAS诱导沉淀法选择性去除血液中的低密度脂蛋白
5. The effects of exercise on soluble low density lipoprotein receptor related protein in the blood of athletes and non-athletes. [D] . Nielsen, Matthew John. 2006

机译：运动对运动员和非运动员血液中可溶性低密度脂蛋白受体相关蛋白的影响。
6. Development of an integrated model for analysis of the kinetics of apolipoprotein B in plasma very low density lipoproteins intermediate density lipoproteins and low density lipoproteins. [O] . W F Beltz, Y A Kesäniemi, B V Howard, 1985

机译：开发了用于分析血浆极低密度脂蛋白中密度脂蛋白和低密度脂蛋白中载脂蛋白B动力学的集成模型。
7. Removal of low density lipoprotein from blood plasma using cross-linked, sulfated polyvinylalcohol [O] . Maaskant N., Bantjes A., Kempen H.J.M. 1986

机译：使用交联的硫酸化聚乙烯醇从血浆中去除低密度脂蛋白

Fe3O4@ZnO core-shell nanocomposites for efficient and repetitive removal of low density lipoprotein in plasma and on blood vessel

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