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首页> 外文期刊>Nanotechnology >Novel synthesis strategy for composite hydrogel of collagen/hydroxyapatite-microsphere originating from conversion of CaCO3 templates
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Novel synthesis strategy for composite hydrogel of collagen/hydroxyapatite-microsphere originating from conversion of CaCO3 templates

机译：CaCO3模板转化产生胶原/羟基磷灰石-微球复合水凝胶的新合成策略

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摘要

Inspired by coralline-derived hydroxyapatite, we designed a methodological route to synthesize carbonated-hydroxyapatite microspheres from the conversion of CaCO3 spherulite templates within a collagen matrix under mild conditions and thus constructed the composite hydrogel of collagen/hydroxyapatite-microspheres. Fourier transform infrared spectroscopy (FTIR) and x-ray diffraction (XRD) were employed to confirm the successful generation of the carbonated hydroxyapatite phase originating from CaCO3, and the ratios of calcium to phosphate were tracked over time. Variations in the weight portion of the components in the hybrid gels before and after the phase transformation of the CaCO3 templates were identified via thermogravimetric analysis (TGA). Scanning electron microscopy (SEM) shows these composite hydrogels have a unique multiscale microstructure consisting of a collagen nanofibril network and hydroxyapatite microspheres. The relationship between the hydroxyapatite nanocrystals and the collagen fibrils was revealed by transmission electron microscopy (TEM) in detail, and the selected area electron diffraction (SAED) pattern further confirmed the results of the XRD analyses which show the typical low crystallinity of the generated hydroxyapatite. This smart synthesis strategy achieved the simultaneous construction of microscale hydroxyapatite particles and collagen fibrillar hydrogel, and appears to provide a novel route to explore an advanced functional hydrogel materials with promising potentials for applications in bone tissue engineering and reconstruction medicine.
机译：受到珊瑚碱衍生的羟基磷灰石的启发，我们设计了一种方法，从温和条件下胶原基质中CaCO3球晶模板的转化来合成碳酸羟基磷灰石微球，从而构建了胶原蛋白/羟基磷灰石微球的复合水凝胶。傅里叶变换红外光谱（FTIR）和X射线衍射（XRD）用于确认成功生成了源自CaCO3的碳酸化羟基磷灰石相，并随时间追踪了钙与磷酸盐的比率。通过热重分析（TGA）鉴定了CaCO3模板相变之前和之后，杂化凝胶中各组分重量的变化。扫描电子显微镜（SEM）显示，这些复合水凝胶具有独特的多尺度微观结构，包括胶原蛋白纳米原纤维网络和羟基磷灰石微球。通过透射电子显微镜（TEM）详细揭示了羟基磷灰石纳米晶体与胶原纤维之间的关系，并且所选区域电子衍射（SAED）模式进一步证实了XRD分析的结果，该结果表明所生成的羟基磷灰石典型的低结晶度。这种智能合成策略实现了同时制备微型羟基磷灰石颗粒和胶原原纤维水凝胶，并似乎为探索一种先进的功能性水凝胶材料提供了一条新颖的途径，该材料在骨组织工程和重建医学中具有广阔的应用前景。

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