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Electrophoretic deposition and characterization of nanocomposites and nanoparticles on magnesium substrates

机译：镁基复合材料上纳米复合材料和纳米颗粒的电泳沉积和表征

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摘要

This study introduces a triphasic design of biodegradable materials composed of nanophase hydroxyapatite (nHA), poly(lactic-co-glycolic acid) (PLGA), and magnesium (Mg) substrates for musculoskeletal implant applications. Specifically, nHA_PLGA composites and nHA nanoparticles were synthesized, deposited on three-dimensional Mg substrates using electrophoretic deposition (EPD), and characterized. The three components involved, that is, nHA, PLGA, and Mg are all biodegradable in the human body, thus promising for biodegradable implant and device applications. Mg and its alloys are attractive for musculoskeletal implant applications due to their comparable modulus and strength to cortical bone. Controlling the interface of Mg with the biological environment, however, is the key challenge that currently limits this biodegradable metal for broad applications in medical implants. This article particularly focuses on creating nanostructured interface between the biodegradable Mg and surrounding tissue for the dual purposes of (1) mediating the degradation of the Mg-based substrates and (2) potentially enhancing osteointegration. Nanophase hydroxyapatite (nHA) is an excellent candidate as a coating material due to its osteoconductivity, while the polymer phase promotes interfacial adhesion between the nHA and Mg. Moreover, the degradation products of PLGA and Mg neutralize each other. Surface characterization showed successful deposition of nHA_PLGA composite microspheres and nHA nanoparticles on Mg substrates using EPD. Mg substrates coated with nHA_PLGA composites showed greater adhesion strength when compared with nHA coating, and slower corrosion rate than nHA coated Mg and non-coated Mg. The triphasic composites of nHA, PLGA and Mg are promising as the next-generation biodegradable materials for medical applications.
机译：这项研究介绍了由纳米相羟基磷灰石（nHA），聚乳酸-乙醇酸（PLGA）和镁（Mg）基质组成的可生物降解材料的三相设计，适用于肌肉骨骼植入应用。具体而言，合成nHA_PLGA复合材料和nHA纳米颗粒，使用电泳沉积（EPD）沉积在三维Mg衬底上，并进行表征。涉及的三个成分，即nHA，PLGA和Mg在人体中都是可生物降解的，因此有望用于可生物降解的植入物和设备应用。镁及其合金具有与皮骨相当的模量和强度，因此对于肌肉骨骼植入物应用具有吸引力。然而，控制镁与生物环境的界面是当前限制这种可生物降解的金属在医学植入物中广泛应用的关键挑战。本文特别着重于在可生物降解的Mg与周围组织之间创建纳米结构界面，其双重目的是（1）介导基于Mg的底物的降解和（2）潜在地增强骨整合。纳米相羟基磷灰石（nHA）由于具有骨传导性，因此是极好的涂料材料，而聚合物相可促进nHA与Mg之间的界面粘合。而且，PLGA和Mg的降解产物彼此中和。表面表征显示，使用EPD，nHA_PLGA复合微球和nHA纳米颗粒成功沉积在Mg衬底上。与nHA涂层相比，涂有nHA_PLGA复合材料的Mg基材显示出更高的粘合强度，并且腐蚀速率比nHA涂层Mg和未涂层Mg慢。 nHA，PLGA和Mg的三相复合材料有望成为医学应用的下一代生物可降解材料。

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