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Source of cytotoxicity in a colloidal silver nanoparticle suspension

机译：胶态银纳米颗粒悬浮液的细胞毒性来源

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Silver nanoparticles (AgNPs) are increasingly used in a variety of applications because of their potential antimicrobial activity and their plasmonic and conductivity properties. In this study, we investigated the source of cytotoxicity, genotoxicity, and reactive oxygen species (ROS) production on human dermal fibroblast and human lung cancer (A549) cell lines upon exposure to AgNP colloidal suspensions prepared with the simplest and most commonly used Lee-Meisel method with a variety of reaction times and the concentrations of the reducing agent. The AgNPs synthesized with shorter reaction times were more cytotoxic and genotoxic due to the presence of a few nanometer-sized AgNP seeds. The suspensions prepared with an increased citrate concentration were not cytotoxic, but they induced more ROS generation on A549 cells due to the high citrate concentration. The genotoxicity of the suspension decreased significantly at the higher citrate concentrations. The analysis of both transmission electron microscopy images from the dried droplet areas of the colloidal suspensions and toxicity data indicated that the AgNP seeds were the major source of toxicity. The completion of the nucleation step and the formation of larger AgNPs effectively decreased the toxicity.
机译：银纳米颗粒（AgNPs）由于其潜在的抗菌活性以及其等离子体和电导特性，越来越多地用于各种应用中。在这项研究中，我们研究了暴露于用最简单和最常用的Lee-迈塞尔法具有多种反应时间和还原剂的浓度。由于存在一些纳米尺寸的AgNP种子，以较短的反应时间合成的AgNP具有更高的细胞毒性和基因毒性。用增加的柠檬酸盐浓度制备的悬浮液没有细胞毒性，但是由于高的柠檬酸盐浓度，它们在A549细胞上诱导更多的ROS产生。在较高的柠檬酸盐浓度下，悬浮液的遗传毒性显着降低。对胶体悬浮液干燥液滴区域的透射电子显微镜图像和毒性数据的分析表明，AgNP种子是毒性的主要来源。成核步骤的完成和较大AgNP的形成有效地降低了毒性。

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