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首页> 外文期刊>Nanotechnology >Dual-mode T-1 and T-2 magnetic resonance imaging contrast agent based on ultrasmall mixed gadolinium-dysprosium oxide nanoparticles: synthesis, characterization, and in vivo application
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Dual-mode T-1 and T-2 magnetic resonance imaging contrast agent based on ultrasmall mixed gadolinium-dysprosium oxide nanoparticles: synthesis, characterization, and in vivo application

机译：基于超小型混合mixed-氧化mixed纳米粒子的双模T-1和T-2磁共振成像造影剂：合成，表征和体内应用

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摘要

A new type of dual-mode T-1 and T-2 magnetic resonance imaging (MRI) contrast agent based on mixed lanthanide oxide nanoparticles was synthesized. Gd3+ (S-8(7/2)) plays an important role in T-1 MRI contrast agents because of its large electron spin magnetic moment resulting from its seven unpaired 4f-electrons, and Dy3+ (H-6(15/2)) has the potential to be used in T-2 MRI contrast agents because of its very large total electron magnetic moment: among lanthanide oxide nanoparticles, Dy2O3 nanoparticles have the largest magnetic moments at room temperature. Using these properties of Gd3+ and Dy3+ and their oxide nanoparticles, ultrasmall mixed gadolinium-dysprosium oxide (GDO) nanoparticles were synthesized and their potential to act as a dual-mode T-1 and T-2 MRI contrast agent was investigated in vitro and in vivo. The D-glucuronic acid coated GDO nanoparticles (d(avg) = 1.0 nm) showed large r(1) and r(2) values (r(2)/r(1) approximate to 6.6) and as a result clear dose-dependent contrast enhancements in R-1 and R-2 map images. Finally, the dual-mode imaging capability of the nanoparticles was confirmed by obtaining in vivo T-1 and T-2 MR images.
机译：合成了一种基于混合镧系氧化物纳米粒子的新型双模式T-1和T-2磁共振成像（MRI）造影剂。 Gd3 +（S-8（7/2））在T-1 MRI造影剂中起重要作用，因为它由七个未配对的4f电子和Dy3 +（H-6（15/2）产生的大电子自旋磁矩）由于其总电子磁矩非常大，因此有可能用于T-2 MRI造影剂：在镧系元素氧化物纳米粒子中，Dy2O3纳米粒子在室温下具有最大的磁矩。利用Gd3 +和Dy3 +及其氧化物纳米粒子的这些特性，合成了超小混合氧化--s氧化（（GDO）纳米粒子，并在体外和体外研究了它们作为T-1和T-2 MRI双模造影剂的潜力。体内。 D-葡萄糖醛酸涂层的GDO纳米颗粒（d（avg）= 1.0 nm）显示出较大的r（1）和r（2）值（r（2）/ r（1）约为6.6），因此，清晰的剂量- R-1和R-2地图图像中依赖对比度的增强。最后，通过获得体内T-1和T-2 MR图像确认了纳米颗粒的双模成像能力。

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