首页> 外文期刊>Nanotechnology >Fabrication and characterization of nanopore-interfaced nanochannel devices
【24h】

Fabrication and characterization of nanopore-interfaced nanochannel devices

机译:纳米孔界面纳米通道器件的制备与表征

获取原文
获取原文并翻译 | 示例
           

摘要

Nanofluidic devices combining nanochannels and nanopores may enable a range of novel applications in the field of single-molecule biosensing and manipulation. Here we combine classic lithographically based fabrication and electron beam milling to construct a device that integrates sealed transverse features, such as nanocavities and nanochannels, with embedded pores vertically intersecting the nanochannels. Using fluorescent microscopy, we demonstrate that DNA molecules can be introduced into the nanochannels and translated transversely across the embedded pore in an extended-conformation without undergoing cross-pore translocation. Upon application of a trans-pore voltage drop, the molecules will undergo cross-pore translocation into an adjoining macroscopic reservoir.
机译:结合了纳米通道和纳米孔的纳米流体装置可以在单分子生物传感和操纵领域实现一系列新颖的应用。在这里,我们将经典的基于光刻的制造与电子束铣削相结合,以构建一种装置,该装置将密封的横向特征(例如纳米腔和纳米通道)与垂直垂直于纳米通道的嵌入式孔集成在一起。使用荧光显微镜,我们证明了DNA分子可以被引入到纳米通道中,并在扩展构型中横穿嵌入的孔横向翻译,而不会发生交叉孔易位。施加跨孔压降后,分子将进行跨孔易位,进入相邻的宏观储层。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号