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首页> 外文期刊>Nanotechnology >Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic field-targeting, highly sensitive MRI and photothermal cancer therapy
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Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic field-targeting, highly sensitive MRI and photothermal cancer therapy

机译：覆有聚多巴胺的超顺磁性氧化铁纳米粒子的纳米簇，用于磁场靶向，高灵敏度MRI和光热癌症治疗

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摘要

In this paper, a core-shell nanocomposite of clusters of superparamagnetic iron oxide nanoparticles coated with poly(dopamine) (SPION clusters@PDA) is fabricated as a magnetic field-directed theranostic agent that combines the capabilities of highly sensitive magnetic resonance imaging (MRI) and photothermal cancer therapy. The highly concentrated SPION cluster core is suitable for sensitive MRI due to its superparamagnetic properties, and the poly (dopamine) coating layer can induce cancer cell death under near-infrared (NIR) laser irradiation because of the photothermal conversion ability of PDA. MRI scanning reveals that the nanocomposite has relatively high r(2) and r(2)* relaxivities, and the r(2)* values are nearly threefold higher than the r2 values because of the clustering of the SPIONs in the nanocomposite core. Due to the rapid response to magnetic field gradients, enhanced cellular uptake of our nanocomposite mediated by an external magnetic field can be achieved, thus producing significantly enhanced local photothermal killing efficiency against cancer cells under NIR irritation.
机译：在本文中，将超顺磁性氧化铁纳米粒子簇包覆聚（多巴胺）（SPION clusters @ PDA）的核-壳纳米复合材料作为一种磁场定向治疗剂，结合了高灵敏度磁共振成像（MRI）的能力）和光热癌症疗法。高浓度的SPION簇核由于具有超顺磁性质而适合于敏感的MRI，而聚（多巴胺）涂层由于PDA的光热转换能力，可在近红外（NIR）激光照射下诱导癌细胞死亡。 MRI扫描显示，纳米复合材料具有相对较高的r（2）和r（2）*弛豫性，并且由于SPIONs在纳米复合材料核心中的聚集，r（2）*值比r2值高将近三倍。由于对磁场梯度的快速响应，可以实现由外部磁场介导的纳米复合材料对细胞吸收的增强，从而在NIR刺激下显着提高了对癌细胞的局部光热杀死效率。

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