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首页> 外文期刊>Nanotechnology >A novel electrospun nerve conduit enhanced by carbon nanotubes for peripheral nerve regeneration
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A novel electrospun nerve conduit enhanced by carbon nanotubes for peripheral nerve regeneration

机译：碳纳米管增强的新型电纺神经导管用于周围神经再生

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For artificial nerve conduits, great improvements have been achieved in mimicking the structures and components of autologous nerves. However, there are still some problems in conduit construction, especially in terms of mechanical properties, biomimetic surface tomography, electrical conductivity and sustained release of neurotrophic factors or cells. In this study, we designed and fabricated a novel electrospun nerve conduit enhanced by multiwalled carbon nanotubes (MWNTs) on the basis of a collagen/poly("caprolactone) (collagen/PCL) fibrous scaffold. Our aim was to provide further knowledge about the mechanical effects and efficacy of MWNTs on nerve conduits as well as the biocompatibility and toxicology of MWNTs when applied in vivo. The results showed that as one component, carboxyl MWNTs could greatly alter the composite scaffold’s hydrophilicity, mechanical properties and degradability. The electrospun fibers enhanced by MWNTs could support Schwann cell adhesion and elongation as a substrate in vitro. In vivo animal studies demonstrated that the MWNTenhanced collagen/PCL conduit could effectively promote nerve regeneration of sciatic nerve defect in rats and prevent muscle atrophy without invoking body rejection or serious chronic inflammation. All of these results showed that this MWNTenhanced scaffold possesses good biocompatibility and MWNTs might be excellent candidates as engineered nanocarriers for further neurotrophic factor delivery research.
机译：对于人造神经导管，在模仿自体神经的结构和组件方面已取得了很大的进步。但是，导管的构造仍然存在一些问题，特别是在机械性能，仿生表面层析成像，电导率以及神经营养因子或细胞的持续释放方面。在这项研究中，我们设计和制造了一种新型的电纺神经导管，该纤维在胶原蛋白/聚（己内酯）（胶原蛋白/ PCL）纤维支架的基础上被多壁碳纳米管（MWNTs）增强。 MWNTs在神经导管中的机械作用和功效以及在体内应用时的生物相容性和毒理学结果表明，羧基MWNTs作为一种成分可以极大地改变复合支架的亲水性，机械性能和降解性，电纺纤维增强MWNTs可以促进雪旺氏细胞的黏附和伸长作为体外的底物。体内动​​物研究表明，MWNTs增强的胶原蛋白/ PCL导管可以有效促进大鼠坐骨神经缺损的神经再生并防止肌肉萎缩而不会引起身体排斥或严重的慢性炎症所有这些结果表明，该MWNT增强支架具有良好的生物相容性。特异度和MWNTs可能是工程化的纳米载体，可用于进一步的神经营养因子递送研究。

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