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Drug encapsulation and release behavior of telechelic nanoparticles

机译：远螯纳米颗粒的药物包封和释放行为

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The encapsulation and release of hydrophobic drug, carbamazepine (CBZ) was investigated using three previously synthesized amphiphilic Lipid-b-poly(ethylene glycol) (Lipid-PEG) conjugates. Their micellization, drug encapsulation, and release behavior was investigated by dynamic light scattering (DLS), transmission electron microscope (TEM), and fluorescence spectroscopy. The highest capacity of drug entrapment was observed for the CPE-PEG-a telechelic with the shorter PEG block and the size of the nanoparticles decreased evidently after the drug was loaded, while a slight decrease in size was also observed for the CPE-PEG-b telechelic with longer PEG block and the three-armed CPE-GE conjugate. TEM images showed that all three types of the drug-loaded micelles had spherical or near-spherical morphology. In the study of the in vitro drug release, slower drug-release patterns were observed for CPE-PEG-a and CPE-GE micelles. Almost all the drug entrapped inside the three types of micelles could be released within 50 h.
机译：使用三种以前合成的两亲脂质-b-聚乙二醇（Lipid-PEG）偶联物研究了疏水性药物卡马西平（CBZ）的包封和释放。通过动态光散射（DLS），透射电子显微镜（TEM）和荧光光谱研究了它们的胶束化，药物封装和释放行为。对于CPE-PEG-a而言，PEG嵌段较短的远螯剂，具有最高的药物截留能力，并且在装载药物后，纳米颗粒的尺寸明显减小，而对于CPE-PEG-，尺寸也略有减小。 b具有更长的PEG嵌段和三臂CPE-GE共轭物的远螯。 TEM图像显示所有三种类型的载药胶束均具有球形或近球形的形态。在体外药物释放的研究中，对于CPE-PEG-a和CPE-GE胶束观察到较慢的药物释放模式。截留在三种胶束中的几乎所有药物都可以在50小时内释放出来。

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