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Recent advances in interactions of designed nanoparticles and cells with respect to cellular uptake, intracellular fate, degradation and cytotoxicity

机译：在细胞摄取，细胞内命运，降解和细胞毒性方面，设计的纳米颗粒与细胞相互作用的最新进展

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摘要

The unique features of nanomaterials have led to their rapid development in the biomedical field. In particular, functionalized nanoparticles (NPs) are extensively used in the delivery of drugs and genes, bio-imaging and diagnosis. Hence, the interaction between NPs and cells is one of the most important issues towards understanding the true nature of the NP-mediated biological effects. Moreover, the intracellular safety concern of the NPs as a result of intracellular NP degradation remains to be clarified in detail. This review presents recent advances in the interactions of designed NPs and cells. The focus includes the governing factors on cellular uptake and the intracellular fate of NPs, and the degradation of NPs and its influence on nanotoxicity. Some basic consideration is proposed for optimizing the NP-cell interaction and designing NPs of better biocompatiblity for biomedical application.
机译：纳米材料的独特特征导致它们在生物医学领域的快速发展。特别是，功能化的纳米颗粒（NPs）被广泛用于药物和基因的传递，生物成像和诊断。因此，NP与细胞之间的相互作用是了解NP介导的生物学效应的真正性质的最重要问题之一。此外，由于细胞内NP降解而导致的NPs的细胞内安全性问题仍需详细阐明。这篇综述介绍了设计的NP和细胞相互作用的最新进展。重点包括影响细胞摄取和NPs的细胞内命运，NPs的降解及其对纳米毒性的影响的控制因素。提出了一些基本的考虑，以优化NP细胞之间的相互作用，并为生物医学应用设计具有更好的生物相容性的NP。

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