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Recent advances in interactions of designed nanoparticles and cells with respect to cellular uptake, intracellular fate, degradation and cytotoxicity

机译:设计纳米粒子和细胞相对于细胞吸收,细胞内命运,降解和细胞毒性相互作用的最新进展

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摘要

The unique features of nanomaterials have led to their rapid development in the biomedical field. In particular, functionalized nanoparticles (NPs) are extensively used in the delivery of drugs and genes, bio-imaging and diagnosis. Hence, the interaction between NPs and cells is one of the most important issues towards understanding the true nature of the NP-mediated biological effects. Moreover, the intracellular safety concern of the NPs as a result of intracellular NP degradation remains to be clarified in detail. This review presents recent advances in the interactions of designed NPs and cells. The focus includes the governing factors on cellular uptake and the intracellular fate of NPs, and the degradation of NPs and its influence on nanotoxicity. Some basic consideration is proposed for optimizing the NP-cell interaction and designing NPs of better biocompatiblity for biomedical application.
机译:纳米材料的独特功能导致了它们在生物医学领域的快速发展。 特别地,官能化纳米颗粒(NPS)被广泛用于递送药物和基因,生物成像和诊断。 因此,NPS和细胞之间的相互作用是理解NP介导的生物效应的真实性质的最重要问题之一。 此外,由于细胞内NP降解的结果,NP的细胞内安全问题仍有待详细阐明。 本综述介绍了设计的NPS和细胞的相互作用的最新进展。 重点包括对细胞摄取和NPS细胞内命运的控制因素,以及NP的降解及其对纳米毒性的影响。 提出了一些基本考虑,用于优化NP细胞相互作用和设计BioCompatibithity的NPS,用于生物医学应用。

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