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Bismuth labeling for the CT assessment of local administration of magnetic nanoparticles

机译：铋标记用于磁性纳米颗粒局部给药的CT评估

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Many therapeutic applications of magnetic nanoparticles involve the local administration of nanometric iron oxide based materials as seeds for magnetothermia or drug carriers. A simple and widespread way of controlling the process using x-ray computed tomography (CT) scanners is desirable. The combination of iron and bismuth in one entity will increase the atenuation of x-rays, offering such a possibility. In order to check this possibility core-shell nanocrystals of iron oxide@bismuth oxide have been synthesized by an aqueous route and stabilized in water by polyethylene glycol (PEG), and we have evaluated their ability to generate contrast by CT and magnetic resonance imaging (MRI) to measure the radiopacity and proton relaxivities using phantoms. High-resolution scanning transmission electron microscopy (STEM) revealed that the material consists of a highly crystalline 8 nm core of maghemite and a 1 nm shell of bismuth atoms either isolated or clustered on the nanocrystal's surface. The comparison of mu CT and MRI images of mice acquired in the presence of the contrast shows that when local accumulations of the magnetic nanoparticles take place, CT images are more superior in the localization of the magnetic nanoparticles than MRI images, which results in magnetic field inhomogeneity artifacts.
机译：磁性纳米粒子的许多治疗应用涉及将纳米氧化铁基材料作为磁疗或药物载体的种子进行局部给药。需要一种使用X射线计算机断层摄影（CT）扫描仪控制过程的简单且广泛的方法。铁和铋在一个实体中的结合会增加X射线的衰减，从而提供这种可能性。为了检验这种可能性，已经通过水合成路线合成了氧​​化铁@氧化铋的核壳纳米晶体，并通过聚乙二醇（PEG）使其在水中稳定，我们评估了它们通过CT和磁共振成像产生对比的能力（核磁共振成像（MRI）以使用幻像仪测量射线不透性和质子弛豫性。高分辨率扫描透射电子显微镜（STEM）显示，该材料由高度结晶的8 nm磁赤铁矿核芯和1 nm的铋原子壳组成，这些壳层孤立或聚集在纳米晶体的表面。在存在对比的情况下获得的小鼠的mu CT和MRI图像的比较表明，当发生磁性纳米颗粒的局部积累时，CT图像在磁性纳米颗粒的定位方面比MRI图像更优越，这导致了磁场不均匀的伪影。

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