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Smart nanocomposite hydrogels based on azo crosslinked graphene oxide for oral colon-specific drug delivery

机译：基于偶氮交联氧化石墨烯的智能纳米复合水凝胶用于口服结肠特异性药物递送

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摘要

A safe and efficient nanocomposite hydrogel for colon cancer drug delivery was synthesized using pH-sensitive and biocompatible graphene oxide (GO) containing azoaromatic crosslinks as well as poly (vinyl alcohol) (PVA) (GO-N=N-GO/PVA composite hydrogels). Curcumin (CUR), an anti-cancer drug, was encapsulated successfully into the hydrogel through a freezing and thawing process. Fourier transform infrared spectroscopy, scanning electron microscopy and Raman spectroscopy were performed to confirm the formation and morphological properties of the nanocomposite hydrogel. The hydrogels exhibited good swelling properties in a pH-sensitive manner. Drug release studies under conditions mimicking stomach to colon transit have shown that the drug was protected from being released completely into the physiological environment of the stomach and small intestine. In vivo imaging analysis, pharmacokinetics and a distribution of the gastrointestinal tract experiment were systematically studied and evaluated as colon-specific drug delivery systems. All the results demonstrated that GO-N=N-GO/PVA composite hydrogels could protect CUR well while passing through the stomach and small intestine to the proximal colon, and enhance the colon-targeting ability and residence time in the colon site. Therefore, CUR loaded GO-N=N-GO/PVA composite hydrogels might potentially provide a theoretical basis for the treatment of colon cancer with high efficiency and low toxicity.
机译：使用含有偶氮芳族交联键的pH敏感且生物相容的氧化石墨烯（GO）以及聚乙烯醇（PVA）（GO-N = N-GO / PVA复合水凝胶）合成了用于结肠癌药物输送的安全有效的纳米复合水凝胶）。姜黄素（CUR）是一种抗癌药物，通过冷冻和解冻过程成功地封装到了水凝胶中。进行了傅里叶变换红外光谱，扫描电子显微镜和拉曼光谱以确认纳米复合水凝胶的形成和形态学性质。水凝胶以pH敏感的方式表现出良好的溶胀性能。在模拟从胃到结肠的转运的条件下的药物释放研究表明，可以防止药物完全释放到胃和小肠的生理环境中。体内成像分析，药代动力学和胃肠道实验的分布进行了系统地研究和评估为结肠特异性药物传递系统。所有结果表明，GO-N = N-GO / PVA复合水凝胶在通过胃和小肠到达近端结肠时可以很好地保护CUR，并提高结肠靶向能力和在结肠部位的停留时间。因此，负载CUR的GO-N = N-GO / PVA复合水凝胶可能为高效率，低毒性的结肠癌治疗提供理论依据。

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