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首页> 外文期刊>Nanotechnology >Water-soluble photoluminescent fullerene capped mesoporous silica for pH-responsive drug delivery and bioimaging
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Water-soluble photoluminescent fullerene capped mesoporous silica for pH-responsive drug delivery and bioimaging

机译：水溶性光致发光富勒烯封端的介孔二氧化硅，用于pH响应药物传递和生物成像

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摘要

In this paper, a biocompatible and water-soluble fluorescent fullerene (C-60-TEG-COOH) coated mesoporous silica nanoparticle (MSN) was successfully fabricated for pH-sensitive drug release and fluorescent cell imaging. The MSN was first reacted with 3-aminopropyltriethoxysilane to obtain an amino-modified MSN, and then the water-soluble C-60 with a carboxyl group was used to cover the surface of the MSN through electrostatic interaction with the amino group in PBS solution (pH = 7.4). The release of doxorubicin hydrochloride (DOX) could be triggered under a mild acidic environment (lysosome, pH = 5.0) due to the protonation of C-60-TEG-COO-, which induced the dissociation of the C-60-TEG-COOH modified MSN (MSN@C-60). Furthermore, the uptake of nanoparticles by cells could be tracked because of the green fluorescent property of the C-60-modified MSN. In an in vitro study, the prepared materials showed excellent biocompatibility and the DOX-loaded nanocarrier exhibited efficient anticancer ability. This work offered a simple method for designing a simultaneous pH-responsive drug delivery and bioimaging system.
机译：本文成功地制备了生物相容的水溶性荧光富勒烯（C-60-TEG-COOH）包被的介孔二氧化硅纳米颗粒（MSN），用于pH敏感的药物释放和荧光细胞成像。首先将MSN与3-氨基丙基三乙氧基硅烷反应以获得氨基修饰的MSN，然后使用具有羧基的水溶性C-60通过与PBS溶液中的氨基进行静电相互作用来覆盖MSN的表面（ pH = 7.4）。由于C-60-TEG-COO-的质子化作用，在温和的酸性环境（溶酶体，pH = 5.0）下，可以触发盐酸阿霉素的释放，从而引起C-60-TEG-COOH的解离。修改后的MSN（MSN @ C-60）。此外，由于C-60修饰的MSN的绿色荧光特性，可以追踪细胞对纳米颗粒的吸收。在体外研究中，制备的材料显示出优异的生物相容性，而载有DOX的纳米载体表现出有效的抗癌能力。这项工作提供了一种简单的方法来设计同时pH响应药物递送和生物成像系统。

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