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首页> 外文期刊>Nanotechnology >Colorimetric determination of Timolol concentration based on localized surface plasmon resonance of silver nanoparticles
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Colorimetric determination of Timolol concentration based on localized surface plasmon resonance of silver nanoparticles

机译：基于银纳米颗粒的局部表面等离子体共振比色法测定噻吗洛尔浓度

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摘要

In this work, a rapid and simple colorimetric method based on the surface plasmon resonance of silver nanoparticles (AgNPs) was developed for the detection of the drug Timolol. The method used is based on the interaction of Timolol with the surface of the as-synthesized AgNPs, which promotes aggregation of the nanoparticles. This aggregation exploits the surface plasmon resonance through the electric dipole-dipole interaction and coupling among the agglomerated particles, hence bringing forth distinctive changes in the spectra as well as the color of colloidal silver. UV-vis spectrophotometery was used to monitor the changes of the localized surface plasmon resonance of AgNPs at wavelengths of 400 and 550 nm. The developed colorimetric sensor has a wide dynamic range of 1.0. x. 10(-7)M-1.0. x. 10(-3)M for detection of Timolol with a low detection limit of 1.2. x. 10(-6) M. The proposed method was successfully applied for the determination of Timolol concentration in ophthalmic eye-drop solution with a response time lower than 40 s.
机译：在这项工作中，开发了一种基于银纳米粒子（AgNPs）的表面等离振子共振的快速，简单的比色方法，用于检测药物Timolol。所使用的方法基于Timolol与合成的AgNPs表面的相互作用，从而促进纳米颗粒的聚集。这种聚集通过电偶极-偶极相互作用和凝聚颗粒之间的耦合来利用表面等离子体共振，从而在光谱以及胶体银的颜色方面产生独特的变化。用紫外可见分光光度计监测AgNP在400和550 nm波长下的局部表面等离振子共振的变化。研发的比色传感器具有1.0的宽动态范围。 X。 10（-7）M-1.0。 X。 10（-3）M用于检测Timolol，检测限低至1.2。 X。 10（-6）M。该方法成功地用于测定眼药水滴眼液中的Timolol浓度，响应时间低于40 s。

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