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首页> 外文期刊>Nanotechnology >Interactions and effects of BSA-functionalized single-walled carbon nanotubes on different cell lines
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Interactions and effects of BSA-functionalized single-walled carbon nanotubes on different cell lines

机译：BSA功能化的单壁碳纳米管在不同细胞系中的相互作用和效应

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Functionalized carbon nanotubes (CNTs) have shown great promise in several biomedical contexts, spanning from drug delivery to tissue regeneration. Thanks to their unique size-related properties, single-walled CNTs (SWCNTs) are particularly interesting in these fields. However, their use in nanomedicine requires a clear demonstration of their safety in terms of tissue damage, toxicity and pro-inflammatory response. Thus, a better understanding of the cytotoxicity mechanisms, the cellular interactions and the effects that these materials have on cell survival and on biological membranes is an important first step for an appropriate assessment of their biocompatibility. In this study we show how bovine serum albumin (BSA) is able to generate homogeneous and stable dispersions of SWCNTs (BSA-CNTs), suggesting their possible use in the biomedical field. On the other hand, this study wishes to shed more light on the impact and the interactions of protein-stabilized SWCNTs with two different cell types exploiting multidisciplinary techniques. We show that BSA-CNTs are efficiently taken up by cells. We also attempt to describe the effect that the interaction with cells has on the dielectric characteristics of the plasma membrane and ion flux using electrorotation. We then focus on the BSA-CNTs' acute toxicity using different cellular models. The novel aspect of this work is the evaluation of the membrane alterations that have been poorly investigated to date.
机译：功能化碳纳米管（CNTs）在从药物输送到组织再生的多种生物医学领域中显示出了巨大的希望。由于其独特的尺寸相关特性，单壁碳纳米管（SWCNT）在这些领域尤为有趣。然而，它们在纳米医学中的用途需要就组织损伤，毒性和促炎反应方面明确证明其安全性。因此，更好地了解细胞毒性机制，细胞相互作用以及这些物质对细胞存活和生物膜的影响，是适当评估其生物相容性的重要的第一步。在这项研究中，我们展示了牛血清白蛋白（BSA）如何能够生成SWCNT（BSA-CNTs）的均质和稳定分散体，表明它们在生物医学领域的可能用途。另一方面，本研究希望通过多学科技术进一步阐明蛋白质稳定的SWCNT与两种不同细胞类型的影响和相互作用。我们表明，BSA-CNT被细胞有效地吸收了。我们还试图描述使用电旋转与细胞相互作用对质膜介电特性和离子通量的影响。然后，我们使用不同的细胞模型重点研究BSA-CNTs的急性毒性。这项工作的新颖之处在于对迄今为止尚未进行充分研究的膜改变的评估。

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