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首页> 外文期刊>NeuroImage >A dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action
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A dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action

机译：背扣带回皮质在反应抑制中的双重但非对称作用以及从非显性作用向显性作用的转换

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Response inhibition and salience detection are among the most studied psychological constructs of cognitive control. Despite a growing body of work, how inhibition and salience processing interact and engage regional brain activations remains unclear. Here, we examined this issue in a stop signal task (SST), where a prepotent response needs to be inhibited to allow an alternative, less dominant response. Sixteen adult individuals performed two versions of the SST each with 25% (SST25) and 75% (SST75) of stop trials. We posited that greater regional activations to the infrequent trial type in each condition (i.e., to stop as compared to go trials in SST25 and to go as compared to stop trials in SST75) support salience detection. Further, successful inhibition in stop trials requires attention to the stop signal to trigger motor inhibition, and the stop signal reaction time (SSRT) has been used to index the efficiency of motor response inhibition. Therefore, greater regional activations to stop as compared to go success trials in association with the stop signal reaction time (SSRT) serve to expedite response inhibition. In support of an interactive role, the dorsal anterior cingulate cortex (dACC) increases activation to salience detection in both SST25 and SST75, but only mediates response inhibition in SST75. Thus, infrequency response in the dACC supports motor inhibition only when stopping has become a routine. In contrast, although the evidence is less robust, the pre-supplementary motor area (pre-SMA) increases activity to the infrequent stimulus and supports inhibition in both SST25 and SST75. These findings clarify a unique role of the dACC and add to the literature that distinguishes dACC and pre-SMA functions in cognitive control. (C) 2016 Elsevier Inc. All rights reserved.
机译：反应抑制和显着性检测是认知控制研究最深入的心理学构造之一。尽管工作量不断增加，但抑制和显着性处理如何相互作用并参与区域性大脑激活的机制仍不清楚。在这里，我们在停止信号任务（SST）中检查了此问题，在该任务中，需要抑制有力的反应，以允许进行替代的，较少主导的反应。 16名成年个体进行了两种版本的SST，分别有25％（SST25）和75％（SST75）的停止试验。我们假设，在每种情况下（例如，与SST25中的Go试验相比要停止，与SST75中的终止试验相比要停止），对罕见试验类型的更大区域激活都支持显着性检测。此外，在停止试验中成功抑制需要注意停止信号以触发运动抑制，并且停止信号反应时间（SSRT）已用于确定运动反应抑制的效率。因此，与通过停止信号反应时间（SSRT）进行的成功试验相比，更大的区域激活停止作用可加快反应抑制。为了支持交互作用，背侧扣带前皮质（dACC）在SST25和SST75中均增强了对显着性检测的激活，但仅介导了SST75中的反应抑制。因此，dACC中的低频响应仅在停止已成为常规时才支持电机禁止。相比之下，尽管证据不足，但补充运动前区域（pre-SMA）可以增加对不频繁刺激的活动并支持SST25和SST75的抑制作用。这些发现阐明了dACC的独特作用，并增加了在认知控制中区分dACC和SMA前功能的文献。 （C）2016 Elsevier Inc.保留所有权利。

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