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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Relationships between plasma leptin concentrations and human brain structure: a voxel-based morphometric study.
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Relationships between plasma leptin concentrations and human brain structure: a voxel-based morphometric study.

机译：血浆瘦素浓度与人脑结构之间的关系：基于体素的形态计量学研究。

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We have previously demonstrated that obese people have reduced grey matter (GM) in several brain areas, including regions implicated in the regulation of taste (i.e., inferior frontal operculum and postcentral gyrus), reward (i.e., putamen), and behavioural processing (i.e., middle frontal gyrus), compared with their lean counterparts. It is well established that the brain may serve as a direct target for adiposity signals, one of the most important being leptin. We investigated the relationships between fasting plasma leptin concentrations and brain tissue composition in a group of 32 young adult Caucasians (12M/20F, age 32+/-1 years, body fat 29+/-1%, mean+/-S.E.) with normal glucose tolerance by using voxel-based morphometry of magnetic resonance imaging scans. Fasting plasma leptin concentrations were positively correlated with GM volumes of the left cerebellum and left inferior temporal gyrus and negatively associated with GM volumes of the left inferior frontal operculum, left postcentral gyrus, and right putamen (P<0.001, uncorrected for multiple comparisons) after adjustment for sex, percent body fat, age, fasting plasma insulin concentrations (i.e., the major determinants of plasma leptin), and global GM volume (thus allowing for an assessment of regional effects only). This study showed an independent, negative correlation between fasting plasma leptin concentrations, which are increased in obesity, and the volumes of GM in brain areas where obese people have reduced GM compared to their lean counterparts. These relationships may explain some of the abnormalities in brain morphology recently found to be associated with excess body fatness.
机译：先前我们已经证明，肥胖者在几个脑部区域减少了灰质（GM），包括与味觉调节有关的区域（即额额下and和中央后回），奖励（即壳核）和行为处理（即，中额额回）与瘦身相比。众所周知，大脑可以作为肥胖信号的直接靶标，最重要的之一就是瘦素。我们调查了一组正常的32名年轻成年高加索人（12M / 20F，年龄32 +/- 1岁，体脂29 +/- 1％，平均值+/- SE）的空腹血浆瘦素浓度与脑组织组成之间的关系。通过使用基于体素的磁共振成像扫描形态计量学对葡萄糖的耐受性。空腹血浆瘦素浓度与左小脑和左下颞回的GM体积呈正相关，与左下额，左中后回和右壳核的GM体积呈负相关（P <0.001，未作多次比较校正）调整性别，体脂百分比，年龄，空腹血浆胰岛素浓度（即血浆瘦素的主要决定因素）和总体GM量（因此仅允许评估区域效应）。这项研究表明，肥胖者增加的空腹血浆瘦素浓度与肥胖人群相比，肥胖人群的GM降低的大脑区域中的GM体积之间存在独立的负相关。这些关系可能解释了最近发现与体内多余脂肪相关的大脑形态异常。

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