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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Combination of chewing and stress up-regulates hippocampal glucocorticoid receptor in contrast to the increase of mineralocorticoid receptor under stress only
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Combination of chewing and stress up-regulates hippocampal glucocorticoid receptor in contrast to the increase of mineralocorticoid receptor under stress only

机译：咀嚼和压力的组合上调海马糖皮质激素受体，而仅在压力下盐皮质激素受体增加

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摘要

In general, acute immobilization stress increases plasma corticosterone levels that signal the hypothalamic-pituitary-adrenal axis. Mineralocorticoid receptors and glucocorticoid receptors in the hippocampus perform crucial roles in this feedback mechanism. In the present study, we investigated the effects of chewing under stress on the rat hippocampal mineralocorticoid and glucocorticoid receptors by immunohistochemistry. We separated rats into a control group, a 2-h immobilization stress group (stress only group), and a 2-h immobilization stress group that was allowed to chew on a wooden stick for the latter 1. h (stress with chewing group). Mineralocorticoid receptor immunoreactive cells with nucleus staining in the hippocampal CA1 area were scattered in the pyramidal cell layer. The stress only group showed the densest distribution of immunoreactive cells; however, the density of the immunoreactive cells in the stress with chewing group was similar to that of the control group. Changes in immunoreactive cell density were not visible in other areas of the hippocampus, namely, the CA3 area and dentate gyrus. Image analysis indicated that the increase in the mineralocorticoid receptor immunoreactive area within a fixed area in the stress only group was statistically significant compared with those in the control group and the stress with chewing group. On the other hand, glucocorticoid receptor immunoreactive cells in the CA1 area seemed to be increased in the stress with chewing group, but not in the stress only group. Image analysis indicated that this increase was statistically significant. These results suggest that immobilization and immobilization with chewing differentially affect these two types of glucocorticoid receptors in the rat hippocampus. Considering that chewing has alleviative effects against stress, glucocorticoid receptor elevation in the hippocampal CA1 area is one of the neuronal mechanisms of coping with stress.
机译：通常，急性固定应激会增加血浆皮质类固醇水平，从而指示下丘脑-垂体-肾上腺轴。海马中的盐皮质激素受体和糖皮质激素受体在这种反馈机制中起着至关重要的作用。在本研究中，我们通过免疫组织化学研究了咀嚼对大鼠海马盐皮质激素和糖皮质激素受体的影响。我们将大鼠分为对照组，2小时固定压力组（仅压力组）和2小时固定压力组，允许后者在木棍上咀嚼后者1. h（咀嚼组压力） 。海马CA1区具有核染色的盐皮质激素受体免疫反应细胞散布在锥体细胞层中。仅应激组显示免疫反应性细胞分布最密集。然而，咀嚼应激组免疫反应细胞的密度与对照组相似。免疫反应性细胞密度的变化在海马的其他区域（即CA3区和齿状回）不可见。图像分析表明，仅应激组中固定区域内盐皮质激素受体免疫反应性区域的增加与对照组和咀嚼组相比具有统计学意义。另一方面，在咀嚼组的应激中，CA1区域的糖皮质激素受体免疫反应性细胞似乎增加了，而在仅应激组中则没有。图像分析表明，这种增加具有统计学意义。这些结果表明，固定和咀嚼固定对大鼠海马中的这两种类型的糖皮质激素受体有不同的影响。考虑到咀嚼对压力有缓解作用，海马CA1区糖皮质激素受体的升高是应对压力的神经元机制之一。

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