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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Differential effects of exercise intensities in hippocampal BDNF, inflammatory cytokines and cell proliferation in rats during the postnatal brain development
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Differential effects of exercise intensities in hippocampal BDNF, inflammatory cytokines and cell proliferation in rats during the postnatal brain development

机译：运动强度对出生后脑发育过程中大鼠海马BDNF，炎性细胞因子和细胞增殖的差异影响

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It has been established that low intensities of exercise produce beneficial effects for the brain, while high intensities can cause some neuronal damage (e.g. exacerbated inflammatory response and cell death). Although these effects are documented in the mature brain, the influence of exercise intensities in the developing brain has been poorly explored. To investigate the impact of exercise intensity in developing rats, we evaluated the hippocampal level of brain derived neurotrophic factor (BDNF), inflammatory cytokines (TNFα, IL6 and IL10) and the occurrence of hippocampal cell degeneration and proliferation at different stages of postnatal brain development of rats submitted to two physical exercise intensities. To this point, male rats were divided into different age groups: P21, P31, P41 and P51. Each age group was submitted to two exercise intensities (low and high) on a treadmill over 10 consecutive days, except the control rats. We verified that the density of proliferating cells was significantly higher in the dentate gyrus of rats submitted to low-intensity exercise from P21 to P30 compared with high-intensity exercise and control rats. A significant increase of proliferative cell density was found in rats submitted to high-intensity exercise from P31 to P40 when compared to low-intensity exercise and control rats. Elevated hippocampal levels of IL6 were detected in rats submitted to high-intensity exercise from P21 to P30 compared to control rats. From P41 to P50 period, higher levels of BDNF, TNFα and IL10 were found in the hippocampal formation of rats submitted to high-intensity exercise in relation to their control rats. Our data show that exercise-induced neuroplastic effects on BDNF levels and cellular proliferation in the hippocampal region are dependent on exercise intensity and developmental period. Thus, exercise intensity is an inflammation-inducing factor and exercise-induced inflammatory response during the postnatal brain development is also related to developmental stage. Our findings indicate that neuroplastic changes induced by exercise in developing rats depend on both age and training intensity.
机译：已经确定，低强度的运动会对大脑产生有益的影响，而高强度的运动会引起一些神经元损伤（例如，炎症反应加重和细胞死亡加剧）。尽管这些作用已在成​​熟的大脑中得到证明，但运动强度对发育中的大脑的影响却鲜有研究。为了研究运动强度对发育中大鼠的影响，我们评估了出生后大脑发育不同阶段的脑源性神经营养因子（BDNF），炎性细胞因子（TNFα，IL6和IL10）的海马水平以及海马细胞变性和增殖的发生接受两种体育锻炼强度的大鼠。至此，将雄性大鼠分为不同的年龄组：P21，P31，P41和P51。除对照组大鼠外，每个年龄组均连续10天在跑步机上接受两种强度的锻炼（低强度和高强度）。我们证实，与高强度运动组和对照组相比，从P21到P30进行低强度运动的大鼠的齿状回中增殖细胞的密度明显更高。与低强度运动组和对照组相比，从P31到P40进行高强度运动的大鼠中增殖细胞密度显着增加。与对照组相比，在从P21到P30进行高强度运动的大鼠中，海马IL6水平升高。从P41至P50期，与对照组相比，高强度运动大鼠海马结构中BDNF，TNFα和IL10水平升高。我们的数据表明，运动引起的对海马区BDNF水平和细胞增殖的神经塑性作用取决于运动强度和发育时期。因此，运动强度是炎症的诱导因子，而运动后炎症在出生后大脑发育过程中也与发育阶段有关。我们的发现表明，在发育中的大鼠中，运动引起的神经塑性变化取决于年龄和训练强度。

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