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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >ALTERATIONS IN THE HIPPOCAMPAL AND STRIATAL CATECHOLAMINERGIC FIBER DENSITIES OF HETEROZYGOUS REELER MICE
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ALTERATIONS IN THE HIPPOCAMPAL AND STRIATAL CATECHOLAMINERGIC FIBER DENSITIES OF HETEROZYGOUS REELER MICE

机译：杂种REE鼠小鼠海马和纹状体儿茶胺能纤维密度的变化

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The heterozygous reeler mouse (HRM), haploin-sufficient for reelin, shares several neurochemical and behavioral similarities with patients suffering from schizophrenia. It has been shown that defective reelin signaling influences the mesolimbic dopaminergic pathways in a specific manner. However, there is only little information about the impact of reelin haploinsufficiency on the monoaminer-gic innervation of different brain areas, known to be involved in the pathophysiology of schizophrenia. In the present study using immunocytochemical procedures, we investigated HRM and wild-type mice (WT) for differences in the densities of tyrosine hydroxylase (TH)-immunoreactive (IR) and serotonin (5-HT)-lR fibers in prefrontal cortex, ventral and dorsal hippocampal formation, amygdala and ventral and dorsal striatum. We found that HRM, compared to WT, shows a significant increase in TH-IR fiber densities in dorsal hippocampal CA1, CA3 and ventral CA1. In contrast, HRM exhibits a significant decrease of TH-IR in the shell of the nucleus accumbens (AcbShell), but no differences in the other brain areas investigated. Overall, no genotype differences were found in the 5-HT-IR fiber densities. In conclusion, these results support the view that reelin haploinsufficiency differentially influences the catecholaminergic (esp. dopaminergic) systems in brain areas associated with schizophrenia. The reelin haploinsufficient mouse may provide a useful model for studying the role of reelin in hippocampal dysfunction and its effect on the dopaminergic system as related to schizophrenia.
机译：杂合的卷轴小鼠（HRM），足以产生reelin的单倍蛋白，与患有精神分裂症的患者有一些神经化学和行为相似之处。已经显示有缺陷的瑞林信号传导以特定方式影响中脑边缘的多巴胺能途径。然而，关于瑞林单倍剂量不足对不同脑区的单胺能神经支配影响的信息很少，已知这与精神分裂症的病理生理有关。在本研究中，我们使用免疫细胞化学方法研究了HRM和野生型小鼠（WT）的前额叶皮层，腹侧酪氨酸羟化酶（TH）-免疫反应性（IR）和血清素（5-HT）-1R纤维的密度差异以及海马背侧形成，杏仁核以及腹侧和背侧纹状体。我们发现，与WT相比，HRM在背侧海马CA1，CA3和腹侧CA1中显示TH-IR纤维密度显着增加。相反，HRM在伏伏核（AcbShell）的外壳中显示出TH-1R的显着降低，但在其他研究的大脑区域中没有差异。总体而言，在5-HT-IR纤维密度中未发现基因型差异。总之，这些结果支持了瑞林单倍机能不足对精神分裂症相关脑区域的儿茶酚胺能（特别是多巴胺能）系统产生不同影响的观点。 reelin单倍体不足的小鼠可能为研究reelin在海马功能障碍中的作用及其对精神分裂症相关的多巴胺能系统的作用提供有用的模型。

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