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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >VITAMIN E IS ESSENTIAL FOR PURKINJE NEURON INTEGRITY
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VITAMIN E IS ESSENTIAL FOR PURKINJE NEURON INTEGRITY

机译：维生素E对PURKINJE神经元的完整性至关重要

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摘要

alpha-Tocopherol (vitamin E) is an essential dietary antioxidant with important neuroprotective functions. alpha-Tocopherol deficiency manifests primarily in neurological pathologies, notably cerebellar dysfunctions such as spi-nocerebellar ataxia. To study the roles of alpha-tocopherol in the cerebellum, we used the alpha-tocopherol transfer protein for the murine version (Ttpa~(-/-)) mice which lack the alpha-tocopherol transfer protein (TTP) and are a faithful model of vitamin E deficiency and oxidative stress. When fed vitamin E-deficient diet, Ttpa~(-/-) mice had un-detectable levels of alpha-tocopherol in plasma and several brain regions. Dietary supplementation with alpha-tocopherol normalized plasma levels of the vitamin, but only modestly increased its levels in the cerebellum and prefrontal cortex, indicating a critical function of brain TTP. Vitamin E deficiency caused an increase in cerebellar oxidative stress evidenced by increased protein nitrosylation, which was prevented by dietary supplementation with the vitamin. Concomitantly, vitamin E deficiency precipitated cellular atrophy and diminished dendritic branching of Purkinje neurons, the predominant output regulator of the cerebellar cortex. The anatomic decline induced by vitamin E deficiency was paralleled by behavioral deficits in motor coordination and cognitive functions that were normalized upon vitamin E supplementation. These observations underscore the essential role of vitamin E and TTP in maintaining CNS function, and support the notion that alpha-tocopherol supplementation may comprise an effective intervention in oxidative stress-related neurological disorders.
机译：α-生育酚（维生素E）是必需的饮食抗氧化剂，具有重要的神经保护功能。 α-生育酚缺乏症主要表现在神经病理学上，尤其是小脑功能障碍，例如spi-小脑共济失调。为了研究α-生育酚在小脑中的作用，我们将α-生育酚转移蛋白用于鼠类（Ttpa〜（-/-））小鼠，该小鼠缺乏α-生育酚转移蛋白（TTP），是一个忠实的模型维生素E缺乏症和氧化应激。当饲喂缺乏维生素E的饮食时，Ttpa〜（-/-）小鼠的血浆和几个大脑区域中的α-生育酚水平无法检测到。膳食补充α-生育酚可使血浆中的维生素水平正常化，但仅适度增加了其在小脑和前额叶皮层中的水平，表明脑TTP的关键功能。维生素E缺乏症引起的小脑氧化应激增加，这是由于蛋白质亚硝化作用增强所致，而饮食中补充维生素可防止这种情况。随之而来的是，维生素E缺乏导致小脑皮层的主要输出调节物Purkinje神经元的细胞萎缩和树突分支减少。维生素E缺乏引起的解剖学下降与运动协调和认知功能的行为缺陷同时发生，这些缺陷在补充维生素E时得以正常化。这些观察结果强调了维生素E和TTP在维持中枢神经系统功能中的重要作用，并支持以下观点：补充α-生育酚可能包括对氧化应激相关神经系统疾病的有效干预。

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