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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >ESTROGENIC REGULATION OF NADPH-DIAPHORASE IN THE SUPRAOPTIC AND PARAVENTRICULAR NUCLEI UNDER ACUTE OSMOTIC STRESS
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ESTROGENIC REGULATION OF NADPH-DIAPHORASE IN THE SUPRAOPTIC AND PARAVENTRICULAR NUCLEI UNDER ACUTE OSMOTIC STRESS

机译：急性渗透压下上，上室核中NADPH-透氨酶的雌激素调节

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Estrogen receptors (ERs) alpha and beta are involved in the regulation of the nitrergic system in the supraoptic (SON) and paraventricular (PVN) nuclei under basal conditions. In this study we have assessed whether ERs are also involved in the modulation of the nitrergic system in the SON and PVN under acute systemic hypertonic conditions. Adult ovariectomized rats received a single injection of either estradiol, a selective ERalpha agonist, a selective ERbeta agonist, a selective ERalpha antagonist, a selective ERbeta antagonist or vehicle. Twenty-four hours later, animals received one i.p. injection of 1.5 M NaCI to induce osmotic stress and were sacrificed after two additional hours. The number of NADPH-diaphorase-positive cells in the SON and PVN was determined. Their number in the SON was not affected by NaCI administration, whereas in the four PVN subdivisions it was decreased after NaCI administration. Estradiol and the ERalpha agonist prevented the action of NaCI in the four subdivisions of the PVN. In contrast, the inhibition of ERalpha enhanced the effect of NaCI, inducing a further decrease in the number of NADPH-diaphorase-positive cells. Moreover, the ERbeta agonist enhanced and the ERp antagonist blocked the effect of NaCI on the number of NADPH-diaphorase-positive neurons in the SON and in the medial magnocellular subdivision of the PVN. These findings indicate that estradiol regulates the nitrergic system in the SON and PVN under acute osmotic stress conditions, but the effects specifically depend on the anatomical subregions and different ERs.
机译：在基础条件下，雌激素受体（ER）α和β参与调节视光（SON）和室旁（PVN）核中的硝化系统。在这项研究中，我们评估了急性系统高渗条件下ER是否也参与SON和PVN中硝化系统的调节。切除卵巢的成年大鼠单次注射雌二醇，选择性ERalpha激动剂，选择性ERbeta激动剂，选择性ERalpha拮抗剂，选择性ERbeta拮抗剂或媒介物。二十四小时后，动物接受了一次腹膜内注射。注射1.5M NaCl以诱导渗透压，并在另外两个小时后处死。确定了SON和PVN中NADPH-黄递酶阳性细胞的数目。在SON中，它们的数量不受NaCI管理的影响，而在四个PVN分区中，在施用NaCI后，其数量减少了。雌二醇和ERalpha激动剂阻止了NaCl在PVN的四个细分区域中的作用。相反，对ERalpha的抑制增强了NaCl的作用，从而导致NADPH-心肌黄递酶阳性细胞数量进一步减少。此外，ERbeta激动剂增强了，ERp拮抗剂阻断了NaCI对SON和PVN的内侧magnocellular细分中NADPH-心肌黄递酶阳性神经元数量的影响。这些发现表明，在急性渗透应激条件下，雌二醇调节SON和PVN中的硝化系统，但其作用具体取决于解剖区域和不同的ER。

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