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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >DENDRITIC SPINE CHANGES ASSOCIATED WITH NORMAL AGING
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DENDRITIC SPINE CHANGES ASSOCIATED WITH NORMAL AGING

机译：正常衰老引起的树突状脊柱变化

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Given the rapid rate of population aging and the increased incidence of cognitive decline and neurodegener-ative diseases with advanced age, it is important to ascertain the determinants that result in cognitive impairment. It is also important to note that much of the aged population exhibit 'successful' cognitive aging, in which cognitive impairment is minimal. One main goal of normal aging studies is to distinguish the neural changes that occur in unsuccessful (functionally impaired) subjects from those of successful (functionally unimpaired) subjects. In this review, we present some of the structural adaptations that neurons and spines undergo throughout normal aging and discuss their likely contributions to electrophysiological properties and cognition. Structural changes of neurons and dendritic spines during aging, and the functional consequences of such changes, remain poorly understood. Elucidating the structural and functional synaptic age-related changes that lead to cognitive impairment may lead to the development of drug treatments that can restore or protect neural circuits and mediate cognition and successful aging.
机译：鉴于人口老龄化的速度很快，随着年龄的增长，认知能力下降和神经退行性疾病的发生率增加，因此重要的是确定导致认知障碍的决定因素。还需要注意的是，许多老年人都表现出“成功的”认知衰老，其中认知障碍最小。正常衰老研究的一个主要目标是，将未成功（功能受损）受试者的神经变化与成功（功能未受损）受试者的神经变化区分开。在这篇综述中，我们介绍了神经元和脊柱在正常衰老过程中所经历的一些结构适应，并讨论了它们对电生理特性和认知的可能贡献。衰老过程中神经元和树突棘的结构变化以及这种变化的功能后果仍然知之甚少。阐明导致认知障碍的与年龄相关的结构和功能性突触变化可能会导致药物治疗的发展，该药物治疗可以恢复或保护神经回路并介导认知和成功的衰老。

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