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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >A CLOSER LOOK AT MECHANISMS UNDERLYING PERCEPTUAL DIFFERENCES IN PARKINSON'S FREEZERS AND NON-FREEZERS
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A CLOSER LOOK AT MECHANISMS UNDERLYING PERCEPTUAL DIFFERENCES IN PARKINSON'S FREEZERS AND NON-FREEZERS

机译：仔细研究帕金森冷冻机和非冷冻机知觉差异的机制

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Parkinson's disease patients who suffer from freezing of gait (PD-FOG) may have sensory and/or perceptual deficits, although they are difficult to disentangle. This study evaluated whether visuospatial perception or self-motion perception were more impaired in PD-FOG, and whether distance estimation errors might be related to misperception of physical walking (compared to imagined). Finally, cognitive status was evaluated in order to evaluate whether cognitive status predicts any of the perception deficits identified. Nine PD-FOG and 15 PD-nonFOG were tested. In experiment 1, participants were shown a target, then the target was removed, before participants demonstrated the original position of the target in two different feedback conditions (pointing with a laser, or walking to its original position). In experiment 2, participants walked to a target (3, 4.5, 6 m) and then imagined walking to that same target. The time to complete both of these tasks was measured and compared. Experiment 1 found a significantly greater judgment error in PD-FOG across both conditions (p = 0.013) (compared to PD-nonFOG). Constant error revealed that both groups significantly underestimated during the self-motion condition only (p = 0.01). Interestingly, results from experiment 2 demonstrated a significant discrepancy between the time it took to imagine walking compared to their actual movement times, specifically in PD-FOG (p = 0.03). This mismatch as well as cognitive status significantly predicted judgment errors during the self-motion condition from experiment 1. Therefore, this study found evidence that PD-FOG have significantly greater sensory-perception deficits compared to PD-nonFOG. These findings have important clinical implications for further understanding FOG and developing new rehabilitative strategies for FOG symptoms.
机译：尽管步态不稳，但患有步态冻结（PD-FOG）的帕金森氏病患者可能会有感觉和/或知觉缺陷。这项研究评估了PD-FOG中视觉空间知觉或自我运动知觉是否更受损，以及距离估计误差是否可能与对身体行走的误解有关（与想象的相比）。最后，对认知状态进行评估，以评估认知状态是否可以预测所识别的任何感知缺陷。测试了9个PD-FOG和15个PD-nonFOG。在实验1中，在向参与者展示目标在两种不同反馈条件下的原始位置（使用激光指向或步行至其原始位置）之前，向参与者显示了目标，然后将其移除。在实验2中，参与者走到一个目标（3、4.5、6 m），然后想象走到那个目标。测量并比较了完成这两项任务的时间。实验1发现，在两种情况下，PD-FOG的判断误差均显着更大（p = 0.013）（与PD-nonFOG相比）。恒定误差显示，两组仅在自运动状态下显着低估了（p = 0.01）。有趣的是，实验2的结果表明，想象的行走时间与实际的运动时间相比存在显着差异，特别是在PD-FOG中（p = 0.03）。这种失配以及认知状态显着预测了来自实验1的自我运动状态下的判断错误。因此，本研究发现，与PD-nonFOG相比，PD-FOG的感觉知觉缺陷明显更大。这些发现对进一步了解FOG和开发新的FOG症状康复策略具有重要的临床意义。

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