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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >CHARACTERIZATION OF L-TYPE VOLTAGE-GATED CA~(2+) CHANNEL EXPRESSION AND FUNCTION IN DEVELOPING CA3 PYRAMIDAL NEURONS
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CHARACTERIZATION OF L-TYPE VOLTAGE-GATED CA~(2+) CHANNEL EXPRESSION AND FUNCTION IN DEVELOPING CA3 PYRAMIDAL NEURONS

机译：形成CA3锥体神经元的L型电压门控CA〜（2+）通道表达和功能的表征

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Voltage-gated calcium channels (VGCCs) play a major role during the development of the central nervous system (CNS). Ca~(2+) influx via VGCCs regulates axonal growth and neuronal migration as well as synaptic plasticity. Specifically, L-type VGCCs have been well characterized to be involved in the formation and refinement of the connections within the CA3 region of the hippocampus. The majority of the growth, formation, and refinement in the CNS occurs during the third trimester of human pregnancy. An equivalent developmental time period in rodents occurs during the first 2 weeks of post-natal life, and the expression pattern of L-type VGCCs during this time period has not been well characterized. In this study, we show that Ca_v1.2 channels are more highly expressed during this developmental period compared to adolescence (post-natal day 30) and that L-type VGCCs significantly contribute to the overall Ca~(2+) currents. These findings suggest that L-type VGCCs are functionally expressed during the crucial developmental period.
机译：电压门控钙通道（VGCC）在中枢神经系统（CNS）的发育过程中起主要作用。通过VGCC的Ca〜（2+）流入可调节轴突生长和神经元迁移以及突触可塑性。具体而言，L型VGCC已被很好地表征为参与海马CA3区域内连接的形成和完善。中枢神经系统的大部分生长，形成和细化发生在人类妊娠的晚期。啮齿类动物的等效发育时期发生在出生后的前两周，并且在该时期内L型VGCC的表达模式尚未得到很好的表征。在这项研究中，我们表明，与青春期（出生后第30天）相比，在这个发育期Ca_v1.2通道表达更高，并且L型VGCC显着促进了总体Ca〜（2+）电流。这些发现表明，L型VGCC在关键的发育期功能性表达。

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