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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >DIFFERENTIAL RESCUE OF SPATIAL MEMORY DEFICITS IN AGED RATS BY L-TYPE VOLTAGE-DEPENDENT CALCIUM CHANNEL AND RYANODINE RECEPTOR ANTAGONISM
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DIFFERENTIAL RESCUE OF SPATIAL MEMORY DEFICITS IN AGED RATS BY L-TYPE VOLTAGE-DEPENDENT CALCIUM CHANNEL AND RYANODINE RECEPTOR ANTAGONISM

机译：L型电压依赖性钙离子通道和瑞丹碱受体拮抗作用对老年大鼠空间记忆缺陷的缓解作用

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摘要

Age-associated memory impairments may result as a consequence of neuroinflammatory induction of intra-cellular calcium (Ca~(+2)) dysregulation. Altered L-type voltage-dependent calcium channel (L-VDCC) and ryanodine receptor (RyR) activity may underlie age-associated learning and memory impairments. Various neuroinflammatory markers are associated with increased activity of both L-VDCCs and RyRs, and increased neuroinflammation is associated with normal aging. In vitro, pharmacological blockade of L-VDCCs and RyRs has been shown to be anti-inflammatory. Here, we examined whether pharmacological blockade of L-VDCCs or RyRs with the drugs nimodipine and dantro-lene, respectively, could improve spatial memory and reduce age-associated increases in microglia activation. Dantrolene and nimodipine differentially attenuated age-associated spatial memory deficits but were not anti-inflammatory in vivo. Furthermore, RyR gene expression was inversely correlated with spatial memory, highlighting the central role of Ca~(+2) dysregulation in age-associated memory deficits.
机译：与神经相关的细胞内钙（Ca〜（+2））调节异常可能导致与年龄相关的记忆障碍。 L型电压依赖性钙通道（L-VDCC）和ryanodine受体（RyR）活性的改变可能是与年龄相关的学习和记忆障碍的基础。各种神经炎症标记物与L-VDCCs和RyRs的活性增加相关，而神经炎症的增加与正常衰老相关。在体外，已证明L-VDCC和RyR的药理学阻断作用是抗炎的。在这里，我们研究了尼莫地平和丹特罗分别对L-VDCCs或RyRs的药理学阻断作用是否可以改善空间记忆并减少与年龄相关的小胶质细胞活化增加。 Dantrolene和尼莫地平差异性地减弱了与年龄相关的空间记忆缺陷，但在体内却未消炎。此外，RyR基因表达与空间记忆成反比，突显了Ca〜（+2）失调在与年龄相关的记忆缺陷中的核心作用。

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