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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >BMP5 EXPRESSION IN THE ADULT RAT BRAIN
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BMP5 EXPRESSION IN THE ADULT RAT BRAIN

机译：BMP5在成年大鼠脑中的表达

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摘要

Bone morphogenetic protein-5 (BMP5), a member of the transforming growth factor-beta (TGF-beta) superfamily, has many effects in several biological events. Although BMP5 expression has been well reported in the early development of the central nervous system (CNS), there is little information about its expression in the adult CNS. Thus, we analyzed BMP5 expression in the adult rat CNS by immunohistochemistry. Abundant BMP5 expression was observed in most neurons, and their dendrites and axons. Furthermore, strong BMP5 expression was also detected in the neuropil of the gray matters with high plasticity, such as the molecular layer of the cerebellum, locus coeruleus, and nucleus of the solitary tract. In addition, we showed BMP5 expression also in astrocytes, ependymal cells and meninges. Our data suggest that BMP5 is widely expressed throughout the adult CNS, and this abundant expression in the adult brain strongly supports the idea that BMP5 plays important roles not only in the developing brain but also in the adult brain. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
机译：骨形态发生蛋白5（BMP5）是转化生长因子β（TGF-beta）超家族的成员，在几种生物学事件中具有多种作用。尽管BMP5表达已在中枢神经系统（CNS）的早期发育中得到了很好的报道，但有关其在成人CNS中表达的信息很少。因此，我们通过免疫组织化学分析了成年大鼠CNS中的BMP5表达。在大多数神经元及其树突和轴突中均观察到大量的BMP5表达。此外，在具有高可塑性的灰色物质的神经纤维中，例如小脑的分子层，蓝斑轨迹和孤立道的核中，也检测到了强烈的BMP5表达。此外，我们还显示了星形胶质细胞，室管膜细胞和脑膜中BMP5的表达。我们的数据表明BMP5在整个成年中枢神经系统中广泛表达，并且这种在成年脑中的丰富表达强烈支持BMP5不仅在发育中的脑中而且在成年脑中都起着重要作用的观点。 （C）2014年IBRO。由Elsevier Ltd.出版。保留所有权利。

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