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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >AN AMINO-TERMINAL FRAGMENT OF HEMOKININ-1 HAS AN INHIBITORY EFFECT ON PRURITIC PROCESSING IN RATS
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AN AMINO-TERMINAL FRAGMENT OF HEMOKININ-1 HAS AN INHIBITORY EFFECT ON PRURITIC PROCESSING IN RATS

机译：Hemokinin-1的氨基末端片段对大鼠瘙痒病有抑制作用

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摘要

Hemokinin-1 (HK-1) is a peptide encoded by the preprotachykinin gene, TAC-4, and shares the hydrophobic carboxyl-terminal (C-terminal) region common to mammalian tachykinin peptides, such as substance P (SP). It is generally believed that C-terminal fragments of SP elicit an excitatory effect, while pretreatment with amino-terminal (N-terminal) fragments of SP inhibits the function of SP; however, there is no available information on HK-1. Therefore, to clarify the characteristics of C-terminal and N-terminal fragments of HK-1, HK-1 was divided into HK-1 (1-5) as the N-terminal fragment and HK-1 (6-11) as the C-terminal fragment based on the similarity of amino acids between HK-1 and SP. Intrathecal administration of HK-1 (6-11) induced scratching behavior similar to HK-1, while HK-1 (1-5) hardly induced scratching. Pretreatment with HK-1 (1-5), however, attenuated scratching induced by HK-1 and SP, whereas pretreatment with SP (1-5) attenuated SP-induced scratching, but not HK-1. Furthermore, intrathecal administration of HK-1 (1-5) and SP (1-5) markedly attenuated the induction of flinching and enhancement of c-Fos expression in the spinal cord following the intradermal administration of formalin, a noxious stimulant, while pretreatment with HK-1 (1-5), but not SP (1-5), markedly attenuated the induction of scratching behavior by subcutaneous administration of pruritic agents, such as serotonin or hista-mine. Taken together, these findings indicate that HK-1 (1-5) suppresses pruritic and nociceptive processing, while SP (1-5) suppresses nociceptive processing. Therefore, it is suggested that HK-1 (1-5) may be a useful tool for revealing pruritic processing and HK-1 may play a crucial role in pruritic processing.
机译：Hemokinin-1（HK-1）是由protaprochykinin基因TAC-4编码的肽，并具有哺乳动物tachykinin肽共有的疏水性羧基末端（C端）区域，例如P物质（SP）。一般认为，SP的C-末端片段会引起兴奋作用，而用SP的氨基末端（N-末端）片段预处理会抑制SP的功能。但是，没有有关HK-1的可用信息。因此，为弄清HK-1的C端和N端片段的特征，将HK-1分为HK-1（1-5）作为N端片段和HK-1（6-11）作为N端片段。基于HK-1和SP之间氨基酸的相似性，确定C端片段。鞘内施用HK-1（6-11）引起的抓挠行为类似于HK-1，而HK-1（1-5）几乎不引起抓挠。然而，用HK-1（1-5）预处理可减弱HK-1和SP诱导的刮擦，而用SP（1-5）预处理可减弱SP诱导的刮擦，但不会抑制HK-1。此外，鞘内注射HK-1（1-5）和SP（1-5）显着减弱了在预处理过程中皮内注射福尔马林（一种有害的刺激物）后脊髓退缩的诱导和c-Fos表达的增强。 HK-1（1-5）而不是SP（1-5）的药物通过皮下施用瘙痒剂（例如5-羟色胺或组织胺）显着减弱了抓挠行为的诱导。综上所述，这些发现表明HK-1（1-5）抑制了瘙痒和伤害性加工，而SP（1-5）抑制了伤害性加工。因此，建议HK-1（1-5）可能是揭示瘙痒症处理的有用工具，而HK-1可能在瘙痒症处理中起关键作用。

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