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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >SINGLE UNIT ACTIVITY OF THE SUPRACHIASMATIC NUCLEUS AND SURROUNDING NEURONS DURING THE WAKE-SLEEP CYCLE IN MICE
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SINGLE UNIT ACTIVITY OF THE SUPRACHIASMATIC NUCLEUS AND SURROUNDING NEURONS DURING THE WAKE-SLEEP CYCLE IN MICE

机译：小鼠苏醒-睡眠周期中的上皮性核和周围神经元的单单位活性

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The suprachiasmatic nucleus (SCN) of the mammalian hypothalamus contains a circadian clock for timing of diverse neuronal, endocrine, and behavioral rhythms, such as the cycle of sleep and wakefulness. Using extracellular single unit recordings, we have determined, for the first time, the discharge activity of individual SCN neurons during the complete wake-sleep cycle in non-anesthetized, head restrained mice. SCN neurons (n = 79) were divided into three types according to their regular (type I; n = 38) or irregular (type II; n = 19) discharge activity throughout the wake-sleep cycle or their quiescent activity during waking and irregular discharge activity during sleep (type III; n - 22). The type I and II neurons displayed a long-duration action potential, while the type III neurons displayed either a short-duration or long-duration action potential. The type I neurons discharged exclusively as single isolated spikes, whereas the type II and III neurons fired as single isolated spikes, clusters, or bursts. The type I and II neurons showed wake-active, wake/paradoxical (or rapid eye movement) sleep-active, or state-unrelated activity profiles and were, respectively, mainly located in the ventral or dorsal region of the SCN. In contrast, the type III neurons displayed sleep-active discharge profiles and were mainly located in the lateral region of the SCN. The majority of type I and II neurons tested showed an increase in discharge rate following application of light to the animal's eyes. Of the 289 extra-SCN neurons recorded, those displaying sleep-active discharge profiles were mainly located dorsal to the SCN, whereas those displaying wake-active discharge profiles were mainly located lateral or dorsolateral to the SCN. This study shows heterogeneity of mouse SCN and surrounding anterior hypothalamic neurons and suggests differences in their topographic organization and roles in mammalian circadian rhythms and the regulation of sleep and wakefulness.
机译：哺乳动物下丘脑的视交叉上核（SCN）包含一个昼夜节律时钟，用于计时各种神经元，内分泌和行为节律，例如睡眠和清醒的周期。使用细胞外单个单位的记录，我们首次确定了在非麻醉的头枕型小鼠的完整唤醒-睡眠周期中单个SCN神经元的放电活性。 SCN神经元（n = 79）根据其在整个睡眠-睡眠周期中的规则放电（I型; n = 38）或不规则（II型; n = 19）或在苏醒和不规则状态下的静态活动分为三种类型睡眠期间的放电活动（III型; n-22）。 I型和II型神经元显示出长期的动作电位，而III型神经元则显示出短期或长时间的动作电位。 I型神经元仅以单个孤立的尖峰放电，而II型和III型神经元以单个孤立的尖峰，簇或爆发放电。 I型和II型神经元表现出觉醒活动，觉醒/反常（或快速眼动）睡眠活动或状态无关的活动曲线，分别主要位于SCN的腹侧或背侧区域。相比之下，III型神经元表现出睡眠活动放电模式，并且主要位于SCN的外侧区域。在动物眼睛上施加光后，测试的大多数I型和II型神经元显示出放电速率增加。在记录的289个SCN外神经元中，显示睡眠活动放电分布的神经元主要位于SCN背侧，而显示睡眠活动放电分布的神经元则主要位于SCN外侧或背外侧。这项研究显示了小鼠SCN和下丘脑前神经元的异质性，并暗示了它们的地形组织和在哺乳动物昼夜节律中的作用以及睡眠和清醒的调节方面的差异。

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