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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >EFFECTS OF EXTREMELY LOW-FREQUENCY ELECTRIC FIELDS AT DIFFERENT INTENSITIES AND EXPOSURE DURATIONS ON MISMATCH NEGATIVITY
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EFFECTS OF EXTREMELY LOW-FREQUENCY ELECTRIC FIELDS AT DIFFERENT INTENSITIES AND EXPOSURE DURATIONS ON MISMATCH NEGATIVITY

机译：不同强度和曝光持续时间下的极低频电场对失配负性的影响

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The effects of extremely low-frequency electric fields (ELF-EFs, 3-300 Hz) on lipid peroxidation levels and antioxidant enzyme activities have been shown in many tissues and plasma after exposure to 50-Hz alternating current (AC) electric fields. However, similar studies investigating brain lipid peroxidation status are limited. Moreover and as far as we know, no study has been conducted to examine mismatch negativity (MMN) response in rats following exposure to a 50-Hz AC electric field. Therefore, the purpose of the study was to investigate different intensities and exposure durations of ELF-EFs on MMN component of event-related potentials (ERPs) as well as apoptosis and oxidative brain damage in rats. Ninety male rats, aged 3 months were used in our study. A total of six groups, composed of 15 animals each, was formed as follows: sham-exposed rats for 2 weeks (C2), sham-exposed rats for 4 weeks (C4), rats exposed to 12-kV/m and 18-kV/m electric fields for 2 weeks (E12-2 and E18-2), rats exposed to 12- and 18-kV/m electric fields for 4 weeks (E12-4 and E18-4). At the end of the experimental period, MMN responses were recorded in urethane-anesthetized rats by electrodes positioned stereotaxically to the surface of the dura. After MMN recordings, animals were killed by exsanguination and their brain tissues were removed for 4-hydroxy-2-nonenal (4-HNE), protein carbonyl and TUNEL analysis. In the current study, different change patterns in ERP parameters were observed dependent on the intensity and exposure duration of ELF-EFs. There were differences in the amplitudes of ERP between the responses to the standard and the deviant tones in all groups. When peak-to-peak amplitude of the difference curves was evaluated, MMN amplitude was significantly decreased in the E18-4 group compared with the C4 group. Additionally, the amount of 4-HNE was increased in all experimental groups compared with the control group. Consequently, it could be concluded that electric field decreased MMN amplitudes possibly induced by lipid peroxidation.
机译：暴露于50 Hz交流（AC）电场后，许多组织和血浆中已显示出极低频电场（ELF-EFs，3-300 Hz）对脂质过氧化水平和抗氧化酶活性的影响。然而，类似的研究脑脂质过氧化状态的研究是有限的。而且，据我们所知，还没有研究检查暴露于50 Hz交流电场后大鼠的失配负（MMN）反应。因此，本研究的目的是研究大鼠相关事件电位（ERP）的MMN组分上ELF-EF的不同强度和暴露持续时间，以及大鼠的凋亡和氧化性脑损伤。在我们的研究中使用了90只3个月大的雄性大鼠。总共形成6组，每组15只动物，组成如下：假暴露大鼠2周（C2），假暴露大鼠4周（C4），暴露于12kV / m和18-kV / m的大鼠kV / m电场持续2周（E12-2和E18-2），大鼠暴露于12和18kV / m电场持续4周（E12-4和E18-4）。在实验期结束时，通过立体定位于硬脑膜表面的电极在氨基甲酸乙酯麻醉的大鼠中记录了MMN反应。 MMN记录后，放血杀死动物，并取出其脑组织进行4-羟基-2-壬烯醛（4-HNE），羰基蛋白和TUNEL分析。在当前的研究中，根据ELF-EF的强度和暴露持续时间，观察到ERP参数的不同变化模式。在所有组中，对标准的响应和偏差音之间的ERP振幅均存在差异。当评估差异曲线的峰峰值幅度时，与C4组相比，E18-4组的MMN幅度显着降低。另外，与对照组相比，所有实验组中4-HNE的量均增加。因此，可以得出结论，电场降低了脂质过氧化可能引起的MMN幅度。

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